Sex differences in cardiovascular and all-cause mortality in nonalcoholic fatty liver disease in the US population

被引:7
|
作者
Ren, Ruirui [1 ]
Zheng, Yang [1 ,2 ]
机构
[1] First Hosp Jilin Univ, Cardiovasc Ctr, Changchun, Jilin, Peoples R China
[2] First Hosp Jilin Univ, Cardiovasc Ctr, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China
关键词
Nonalcoholic fatty liver disease; Sex differences; Cardiovascular outcomes; GAMMA-GLUTAMYL-TRANSFERASE; RISK-FACTORS; NAFLD; ATHEROSCLEROSIS; EVENTS; GENDER; AGE;
D O I
10.1016/j.numecd.2023.03.003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and aims: Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent chronic liver condition. In the United States (US), the prevalence of NAFLD in men is higher than that in women. This study aimed to evaluate sex differences in long-term all-cause and cardio-vascular (CV) outcomes in patients with NAFLD. Methods and results: We collected data from participants aged >18 years from the National Health and Nutrition Examination Surveys, 2000-2014, which included seven continuous 2 -year surveys. A US Fatty Liver Index score of >30 was used to define NAFLD. We used a weighted Cox proportional hazards model to compare sex differences in overall and CV mortality. The all-cause and CV mortality rates were obtained from the National Center for Health Statistics. From the selected 2627 participants with NAFLD, 65.4% were males. Men had a significantly higher all-cause mortality than women (12.4% vs. 7.7%; p = 0.005), and the risk of CV death was higher in women with NAFLD aged <60 years (adjusted hazard ratio 0.214, 95% confidence interval 0.053-0.869, p = 0.031). Men with a body mass index >30 kg/m2 and diabetes showed a higher risk of all-cause mortality. Sex differences in CV events were not apparent in the patients aged >60 years. Conclusion: Male sex was associated with all-cause mortality in all the age groups. However, CV death is influenced by age, with a higher risk in young and middle-aged women and no apparent difference in older patients. & COPY; 2023 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Ital-ian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:1349 / 1357
页数:9
相关论文
共 50 条
  • [31] Sex differences in temperature-related all-cause mortality in the Netherlands
    Mireille A. Folkerts
    Peter Bröde
    W. J. Wouter Botzen
    Mike L. Martinius
    Nicola Gerrett
    Carel N. Harmsen
    Hein A. M. Daanen
    International Archives of Occupational and Environmental Health, 2022, 95 : 249 - 258
  • [32] Sex differences in the association between albumin and all-cause and vascular mortality
    Grimm, G.
    Haslacher, H.
    Kampitsch, T.
    Endler, G.
    Marsik, C.
    Schickbauer, T.
    Wagner, O.
    Jilma, B.
    EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2009, 39 (10) : 860 - 865
  • [33] Sex differences in temperature-related all-cause mortality in the Netherlands
    Folkerts, Mireille A.
    Broede, Peter
    Botzen, W. J. Wouter
    Martinius, Mike L.
    Gerrett, Nicola
    Harmsen, Carel N.
    Daanen, Hein A. M.
    INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, 2022, 95 (01) : 249 - 258
  • [34] The association of renal impairment with all-cause and cardiovascular disease mortality
    Nitsch, Dorothea
    Lawlor, Debbie A.
    Patel, Rita
    Carson, Claire
    Ebrahim, Shah
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2010, 25 (04) : 1191 - 1199
  • [35] Modifiable lifestyle risks, cardiovascular disease, and all-cause mortality
    Ahmed, Haitham M.
    Blaha, Michael J.
    Blumenthal, Roger S.
    INTERNATIONAL JOURNAL OF CARDIOLOGY, 2014, 172 (01) : E199 - E200
  • [36] Association between prognostic nutritional index and all-cause mortality and cardiovascular disease mortality in American adults with non-alcoholic fatty liver disease
    Lei, Yuqing
    Tao, Shaohong
    Yang, Yubo
    Xie, Fang
    Xie, Weining
    FRONTIERS IN NUTRITION, 2025, 12
  • [37] Association of serum C-peptide with all- cause and cardiovascular disease mortality in ultrasound-defined nonalcoholic fatty liver disease
    Zhao, Enfa
    Chen, Shimin
    CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY, 2022, 46 (10)
  • [38] Nonalcoholic Fatty Liver Disease and Cardiovascular Disease: a Review of Shared Cardiometabolic Risk Factors
    Muzurovic, Emir
    Peng, Carol Chiung-Hui
    Belanger, Matthew J.
    Sanoudou, Despina
    Mikhailidis, Dimitri P.
    Mantzoros, Christos S.
    HYPERTENSION, 2022, 79 (07) : 1319 - 1326
  • [39] Association between Lifestyle Modification and All-Cause, Cardiovascular, and Premature Mortality in Individuals with Non-Alcoholic Fatty Liver Disease
    Huang, Yanqiu
    Xu, Jinfan
    Yang, Yang
    Wan, Tingya
    Wang, Hui
    Li, Xiaoguang
    NUTRIENTS, 2024, 16 (13)
  • [40] Association of Total Bilirubin With All-Cause and Cardiovascular Mortality in the General Population
    Chen, Ziwei
    He, Jing
    Chen, Chu
    Lu, Qi
    FRONTIERS IN CARDIOVASCULAR MEDICINE, 2021, 8