Isothiouronium-Mediated Conversion of Carboxylic Acids to Cyanomethyl Thioesters

被引：5

作者：

Maulide, Nuno ^{[1
]}

Tiefenbrunner, Irmgard ^{[1
]}

Brutiu, Bogdan R. ^{[1
]}

Stopka, Tobias ^{[1
]}

机构：

[1] Univ Vienna, Inst Organ Chem, A-1090 Vienna, Austria

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 06期

基金：

欧洲研究理事会; 奥地利科学基金会;

关键词：

THIOACETIC ACID; UBIQUITIN; ALDEHYDES; THIOLS;

D O I：

10.1021/acs.joc.2c02902

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report the development of an isothiouronium salt as a reagent for the operationally simple synthesis of cyanomethyl thioesters with high functional group tolerance and avoiding the use of thiols. Additionally, we show that the products can be engaged in amide synthesis in either a two-step or one-pot fashion.

引用

页码：3941 / 3944

页数：4

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