Decoding the roles of heat shock proteins in liver cancer

被引：2
|
作者：
Sun, Chen [1 ]
Pan, Qi [2 ]
Du, Mingyang [1 ]
Zheng, Jiahe [1 ]
Bai, Ming [3 ]
Sun, Wei [4 ]
机构：
[1] China Med Univ, Shengjing Hosp, Dept Radiol, Shenyang 110004, Peoples R China
[2] China Med Univ, Hosp 1, Dept Hepatobiliary Surg & Organ Transplantat, Shenyang 110004, Peoples R China
[3] China Med Univ, Hosp 1, Dept Med Oncol 2, Shenyang 110001, Peoples R China
[4] China Med Univ, Shengjing Hosp, Dept Radiol, Shenyang, Liaoning, Peoples R China
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2024年 / 75卷
关键词：
Hepatocellular carcinoma; Heat shock protein; Tumorigenesis; Diagnosis; Therapy; HEPATOCELLULAR-CARCINOMA CELLS; DENDRITIC CELLS; GLUTAMINE-SYNTHETASE; MOLECULAR CHAPERONE; HSP90; INHIBITOR; REVERSE-TRANSCRIPTASE; DOWN-REGULATION; UP-REGULATION; TUMOR-CELLS; IN-VITRO;
D O I：
10.1016/j.cytogfr.2023.12.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hepatocellular carcinoma (HCC) is one of the most common gastrointestinal malignancies, characterized by insidious onset and high propensity for metastasis and recurrence. Apart from surgical resection, there are no effective curative methods for HCC in recent years, due to resistance to radiotherapy and chemotherapy. Heat shock proteins (HSP) play a crucial role in maintaining cellular homeostasis and normal organism development as molecular chaperones for intracellular proteins. Both basic research and clinical data have shown that HSPs are crucial participants in the HCC microenvironment, as well as the occurrence, development, metastasis, and resistance to radiotherapy and chemotherapy in various malignancies, particularly liver cancer. This review aims to discuss the molecular mechanisms and potential clinical value of HSPs in HCC, which may provide new insights for HSP-based therapeutic interventions for HCC.
引用
收藏
页码：81 / 92
页数：12
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