Immunogenicity and safety of COVID-19 vaccines among people living with HIV: A systematic review and meta-analysis

被引：4

作者：

Zhao, Tianyu ^{[1
]}

Yang, Zongxing ^{[2
]}

Wu, Yuxia ^{[1
]}

Yang, Jin ^{[1
,3
]}

机构：

[1] Hangzhou Normal Univ, Inst Hepatol & Metab Dis, Hangzhou, Peoples R China

[2] Zhejiang Chinese Med Univ, Xixi Hosp Hangzhou, Affiliated Hosp, Dept Infect Dis 2, Hangzhou, Peoples R China

[3] Hangzhou Normal Univ, Affiliated Hosp, Dept Translat Med Ctr, Hangzhou, Peoples R China

来源：

EPIDEMIOLOGY & INFECTION | 2023年 / 151卷

关键词：

COVID-19; HIV; immunization (vaccination); safety; vaccines; SARS-COV-2; VACCINATION; NEUTRALIZATION; INFECTION; VARIANT;

D O I：

10.1017/S095026882300153X

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Available data suggest that the immunogenicity of COVID-19 vaccines might decrease in the immunocompromised population, but data on vaccine immunogenicity and safety among people living with HIV (PLWH) are still lacking. The purpose of this meta-analysis is to compare the immunogenicity and safety of COVID-19 vaccines in PLWH with healthy controls. We comprehensively searched the following databases: PubMed, Cochrane Library, and EMBASE. The risk ratio (RR) of seroconversion after the first and second doses of a COVID-19 vaccine was separately pooled using random-effects meta-analysis. Seroconversion rate was lower among PLWH compared with healthy individuals after the first (RR = 0.77, 95% con?dent interval (CI) 0.64-0.92) and second doses (RR = 0.97, 95%CI 0.95-0.99). The risk of total adverse reactions among PLWH is similar to the risk in the healthy group, after the first (RR = 0.87, 95%CI 0.70-1.10) and second (RR = 0.83, 95%CI 0.65-1.07) doses. This study demonstrates that the immunogenicity and safety of SARS-CoV-2 vaccine in fully vaccinated HIV-infected patients were generally satisfactory. A second dose was related to seroconversion enhancement. Therefore, we considered that a booster dose may provide better seroprotection for PLWH. On the basis of a conventional two-dose regimen for COVID-19 vaccines, the booster dose is very necessary.

引用

页数：10

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