Unveiling the Intricacies of Autophagy in Asthma: Unraveling Novel Therapeutic Avenues

被引：1
作者：
Peng, Junjun [1 ]
Lu, Na [2 ]
Hua, Shucheng [1 ]
Song, Lei [1 ,3 ]
Liu, Han [1 ]
机构：
[1] First Hosp Jilin Univ, Dept Resp Med, Changchun 130021, Jilin, Peoples R China
[2] Hebei Med Univ, Dept Emergency Intens Care Med, Hosp 1, Shijiazhuang 050051, Hebei, Peoples R China
[3] Meihekou City Cent Hosp, Dept Resp Med, Meihekou 135000, Jilin, Peoples R China
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2024年 / 29卷 / 01期
基金：
中国国家自然科学基金;
关键词：
neutrophil; eosinophil; paucigranulocytic; phenotypes; treatment; NEUTROPHIL EXTRACELLULAR TRAPS; AIRWAY INFLAMMATION; EPITHELIAL-CELLS; NONEOSINOPHILIC ASTHMA; INTERLEUKIN-17; FAMILY; MITOCHONDRIAL-DNA; DOUBLE-BLIND; RECEPTOR; IL-10; MODULATION;
D O I：
10.31083/j.fbl2901022
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Understanding the pathogenesis of different phenotypes of asthma, including glucocorticoid-dependent and glucocorticoid-resistant asthma, is crucial for the development of effective treatments. Autophagy, a fundamental cellular process involved in cell homeostasis, has been implicated in asthma, although the exact mechanisms remain unclear. Recent studies have identified autophagy activation in eosinophilic, neutrophilic, and paucigranulocytic asthma, providing novel insights into the disease. This comprehensive review examines the role of autophagy in the pathogenesis and treatment of asthma, with a focus on various cell types. The goal is to uncover potential therapeutic targets and innovative treatment modalities to improve patient outcomes in clinical settings.
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页数：14
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