microRNAs and their therapeutic strategy in phase I and phase II clinical trials

被引：15
作者：
Ameya, K. P. [1 ]
Kaliaperumal, Kumaravel [2 ]
Sekar, Durairaj [1 ]
机构：
[1] Saveetha Univ, Saveetha Dent Coll & Hosp, Saveetha Inst Med & Tech Sci SIMATS, RNA Biol Lab, Chennai 600077, India
[2] Saveetha Univ, Saveetha Dent Coll, Dept Orthodont, Unit Biomat Res, Chennai 600077, Tamil Nadu, India
来源：
EPIGENOMICS | 2024年 / 16卷 / 04期
关键词：
clinical trials; diseases; miRNAs; miRNA therapeutics; signaling pathway; CANCER; DELIVERY; BIOMARKERS; PATHWAY; DISEASE; DRUG;
D O I：
10.2217/epi-2023-0363
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
miRNAs play a crucial therapeutic role in diseases such as cancer, diabetes and viral infections, with around 1900 identified in the human genome. Some have progressed to clinical trials, and miRNA mimics and miRNA inhibitors are pivotal therapeutic molecules undergoing evaluation. The review delves into various miRNA-associated clinical trials, emphasizing their precision in targeting specific genes, modulating disease pathways and diagnostic potential. This underscores the importance of miRNA therapy, foreseeing innovations in precision medicine techniques for diverse diseases. The future envisions improved delivery systems addressing challenges like immunogenicity and digestion, while a comprehensive miRNA-based omics database could guide the development of tailored antisense miRNAs, further advancing precision medicine strategies.
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页数：14
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