Frailty-Related Factors among Women Living with and without HIV Aged 40 Years and Older. The Women's Interagency HIV Study

被引：1

作者：

Gustafson, Deborah R. ^{[1
]}

Shi, Q. ^{[2
]}

Thurn, M. ^{[3
]}

Holman, S. ^{[1
]}

Kuniholm, M. H. ^{[4
]}

Fischl, M. ^{[5
]}

Floris-Moore, M. ^{[6
]}

Gange, S. ^{[7
]}

Konkle-Parker, D. ^{[8
,9
,10
]}

Plankey, M. ^{[11
]}

Price, J. C. ^{[12
]}

Ross, R. D. ^{[13
]}

Rubtsova, A. ^{[14
]}

Sharma, A. ^{[15
]}

Hoover, D. R. ^{[16
,17
]}

机构：

[1] SUNY Downstate Hlth Sci Univ, Brooklyn, NY USA

[2] New York Med Coll, Sch Hlth Sci & Practice, Valhalla, NY USA

[3] UNAIDS, Geneva, Switzerland

[4] SUNY Albany, Dept Epidemiol & Biostat, Rensselaer, NY USA

[5] Univ Miami, Miami, FL USA

[6] Univ N Carolina, Div Infect Dis, Chapel Hill, NC 27515 USA

[7] Johns Hopkins Univ, Baltimore, MD USA

[8] Univ Mississippi, Med Ctr, Sch Nursing, University, MS USA

[9] Univ Mississippi, Med Ctr, Sch Med, University, MS USA

[10] Univ Mississippi, Med Ctr, Sch Populat Hlth, University, MS USA

[11] Georgetown Univ, Med Ctr, Dept Med, Washington, DC USA

[12] Univ Calif San Francisco, San Francisco, CA 94143 USA

[13] Rush Univ, Chicago, IL USA

[14] Emory Univ, Atlanta, GA USA

[15] Albert Einstein Coll Med, New York, NY USA

[16] Rutgers State Univ, Dept Stat, New Brunswick, NJ USA

[17] Rutgers State Univ, Inst Hlth Hlth Care Policy & Aging Res, New Brunswick, NJ USA

来源：

JOURNAL OF FRAILTY & AGING | 2024年 / 13卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Frailty; aging; HIV; women; UNINFECTED WOMEN; PHENOTYPE; RISK; INDIVIDUALS; PREVALENCE; DISABILITY; INFECTION;

D O I：

10.14283/jfa.2023.41

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background: Frailty is a clinical, geriatric syndrome linked to disability and mortality; and may be associated with a variety of factors among underrepresented and underserved women living with HIV (WLWH) and without HIV (WLWOH) transitioning through the adult life course.Objectives: Determine whether a published set of factors associated cross-sectionally with frailty in WLWH and similar WLWOH at average age 39 years in 2005/2006 were associated with frailty in 2018/2019 among women who initiated frailty assessments at age >= 40 years, or whether a new set of factors were associated with frailty.Design: Cross-sectional analyses within a longitudinal cohort study.Setting: The multi-center Women's Interagency HIV Study (WIHS).Participants1285 participants (951 WLWH, 334 WLWOH), median age 53 years (interquartile range 47-58 years).Measurements: The Fried Frailty Phenotype (FFP) in association with 23 factors representing HIV serostatus, other infections, sociodemographic factors, health behaviors, and chronic diseases.Results: Frailty prevalence was 11.1% in 2018/2019 (12.6% among WLWOH, 9.6% among WLWH, p=0.121). The published 2005/2006 final multivariable stepwise regression model contained 9 predictors of frailty. When refit to women in 2018/2019, only age >= 50 years and annual income <=$12,000 were independently positively associated with frailty; other significant 2005/2006 factors, HIV serostatus, CD4+ count <500 cells/mL among WLWH, smoking, drinking, FIB-4 and eGFR, were not. A newly-derived stepwise model considering all 23 predictors measured in 2018/2019, showed independent positive associations between frailty and age >= 50 years, annual income <=$12,000, obesity (body mass index (BMI) >= 30kg/m2), and history of tuberculosis and cancer.Conclusion: Different chronic and infectious disease factors were associated with frailty among WLWH and WLWOH over the adult life course. Understanding factors associated with frailty by adult life stage, allows identification and implementation of novel, temporal interventions to alleviate frailty-associated outcomes and enhance quality of life among WLWH and WLWOH.

引用

页码：40 / 49

页数：10