Adult epilepsy

被引:114
作者
Asadi-Pooya, Ali A. [1 ,2 ]
Brigo, Francesco [3 ,4 ]
Lattanzi, Simona [5 ]
Blumcke, Ingmar [6 ,7 ]
机构
[1] Shiraz Univ Med Sci, Epilepsy Res Ctr, Shiraz 71437, Iran
[2] Thomas Jefferson Univ, Jefferson Comprehens Epilepsy Ctr, Dept Neurol, Philadelphia, PA USA
[3] Hosp Merano SABES ASDAA, Dept Neurol, Merano, Italy
[4] Lehrkrankenhaus Paracelsus Med Privatuniv, Salzburg, Austria
[5] Marche Polytech Univ, Dept Expt & Clin Med, Neurol Clin, Ancona, Italy
[6] Univ Hosp Erlangen, Inst Neuropathol, Erlangen, Germany
[7] Cleveland Clin, Neurol Inst, Charles Shor Epilepsy Ctr, Cleveland, OH USA
关键词
PSYCHOGENIC NONEPILEPTIC SEIZURES; TEMPORAL-LOBE EPILEPSY; STATUS EPILEPTICUS; ALTERNATIVE MEDICINE; ANTIEPILEPTIC DRUGS; SURGICAL OUTCOMES; ILAE COMMISSION; FOCAL EPILEPSY; TASK-FORCE; SURGERY;
D O I
10.1016/S0140-6736(23)01048-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Epilepsy is a common medical condition that affects people of all ages, races, social classes, and geographical regions. Diagnosis of epilepsy remains clinical, and ancillary investigations (electroencephalography, imaging, etc) are of aid to determine the type, cause, and prognosis. Antiseizure medications represent the mainstay of epilepsy treatment: they aim to suppress seizures without adverse events, but they do not affect the underlying predisposition to generate seizures. Currently available antiseizure medications are effective in around two-thirds of patients with epilepsy. Neurosurgical resection is an effective strategy to reach seizure control in selected individuals with drug-resistant focal epilepsy. Non-pharmacological treatments such as palliative surgery (eg, corpus callosotomy), neuromodulation techniques (eg, vagus nerve stimulation), and dietary interventions represent therapeutic options for patients with drug-resistant epilepsy who are not suitable for resective brain surgery.
引用
收藏
页码:412 / 424
页数:13
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