Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19: the PHOSP-COVID analysis

被引：7

作者：

Dawson, Camilla ^{[1
,2
]}

Clunie, Gemma ^{[3
]}

Evison, Felicity ^{[4
]}

Duncan, Sallyanne ^{[5
]}

Whitney, Julie ^{[6
]}

Houchen-Wolloff, Linzy ^{[7
]}

Bolton, Charlotte E. ^{[8
]}

Leavy, Olivia C. ^{[9
]}

Richardson, Matthew ^{[10
]}

Omer, Elneima ^{[11
]}

McAuley, Hamish ^{[12
]}

Shikotra, Aarti ^{[13
]}

Singapuri, Amisha ^{[11
]}

Sereno, Marco ^{[11
]}

Saunders, Ruth M. ^{[14
]}

Harris, Victoria C. ^{[11
]}

Greening, Neil J. ^{[15
,16
]}

Nolan, Claire Marie ^{[17
]}

Wootton, Dan Gower ^{[18
]}

Daynes, Enya ^{[19
]}

Donaldson, Gavin ^{[20
]}

Sargent, Jack ^{[21
]}

Scott, Janet ^{[22
]}

Pimm, John ^{[23
]}

Bishop, Lettie ^{[24
]}

McNarry, Melitta ^{[25
]}

Hart, Nicholas ^{[26
]}

Evans, Rachael A. ^{[12
]}

Singh, Sally ^{[27
]}

Yates, Tom ^{[12
]}

Chalder, Trudie ^{[28
]}

Man, William ^{[20
]}

Harrison, Ewen ^{[29
]}

Docherty, Annemarie ^{[29
]}

Lone, Nazir, I ^{[29
]}

Quint, Jennifer K. ^{[20
,30
]}

Chalmers, James ^{[31
]}

Ho, Ling-Pei ^{[32
,33
]}

Horsley, Alex Robert ^{[34
]}

Marks, Michael ^{[35
]}

Poinasamy, Krisnah ^{[36
]}

Raman, Betty ^{[37
,38
]}

Wain, Louise, V ^{[39
,40
]}

Brightling, Chris ^{[41
]}

PHOSP-COVID Collaborative Grp, Neil

Sharma, Neil ^{[42
,43
]}

Coffey, Margaret ^{[20
]}

Kulkarni, Amit ^{[44
]}

Wallace, Sarah ^{[45
]}

机构：

[1] Univ Hosp Birmingham NHS Fdn Trust, Dept Speech & Language Therapy, Birmingham, England

[2] Univ Birmingham, Inst Clin Sci, Coll Med & Dent Sci, Birmingham, England

[3] Imperial Coll London, Dept Surg & Canc, London, England

[4] Univ Hosp Birmingham NHS Fdn Trust, Dept Informat, Birmingham, England

[5] Queens Univ Belfast, Wellcome Wolfson Inst Expt Med, Belfast, North Ireland

[6] Kings Coll London, Fac Life Sci & Med, London, England

[7] Univ Hosp Leicester, Dept Pulm Rehabil, Leicester, England

[8] Univ Nottingham, NIHR Nottingham Biomed Res Ctr Resp Theme, Resp Med, Nottingham, England

[9] Univ Leicester, Dept Hlth Sci, Leicester, England

[10] Natl Inst Hlth Res, Leicester Resp Biomed Res Unit, Leicester, England

[11] Univ Leicester, Inst Lung Hlth, NIHR Leicester Biomed Res Ctr, Leicester, England

[12] Univ Leicester, Leicester, England

[13] Univ Leicester, NIHR Leicester Biomed Res Ctr, Leicester, England

[14] Univ Leicester, Inst Lung Hlth, NIHR Leicester Biomed Res Ctr, Dept Infect Immun & Inflammat, Leicester, England

[15] Univ Leicester, Resp Sci, Leicester, England

[16] Inst Lung Hlth, Resp Med, London, England

[17] Royal Brompton & Harefield Hosp, London, England

[18] Aintree Univ Hosp NHS Fdn Trust, Resp Res, Liverpool, England

[19] NIHR Leicester Biomed Res Ctr, CERS, Leicester, England

[20] Imperial Coll London, London, England

[21] Univ Hosp Leicester NHS Trust, Leicester, England

[22] Univ Glasgow, Glasgow, Scotland

[23] Oxford Hlth NHS Fdn Trust, Buckinghamshire IAPT Serv, Hlth Minds, Oxford, England

[24] Loughborough Univ, Loughborough, England

[25] Swansea Univ, Coll Engn, Swansea, Wales

[26] Guys & St Thomas NHS Fdn Trust, Lane Fox Resp Serv, London, England

[27] Univ Hosp Leicester NHS Trust, Cardiac Pulm Rehabil, Leicester, England

[28] Kings Coll London, London, England

[29] Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Scotland

[30] Imperial Coll London, NHLI, London, England

[31] Univ Dundee, Tayside Resp Res Grp, Dundee, Scotland

[32] Weatherall Inst Mol Med, MRC Human Immunol Unit, Oxford, England

[33] Churchill Hosp, Oxford Ctr Resp Med, Oxford, England

[34] Manchester Adult Cyst Fibrosis Ctr, Resp Med, Manchester, England

[35] London Sch Hyg & Trop Med, London, England

[36] Asthma UK, Res & Innovat Advocacy, London, England

[37] Univ Oxford, Radcliffe Dept Med, Div Cardiovasc Med, Oxford, England

[38] Univ Oxford, Oxford, England

[39] Natl Inst Hlth Res, Biomed Res Ctr Resp, Leicester, England

[40] Univ Leicester, Dept Hlth Sci, Genet Epidemiol Grp, Leicester, England

[41] Univ Leicester, Inst Lung Hlth, Leicester, England

[42] Univ Birmingham, Inst Canc & Genom Sci, Birmingham, England

[43] Univ Hosp Birmingham NHS Fdn Trust, Otolaryngol Head & Neck Surg, Birmingham, England

[44] Royal Coll Speech & Language Therapists, London, England

[45] Wythenshawe Hosp, Manchester, England

来源：

BMJ OPEN RESPIRATORY RESEARCH | 2023年 / 10卷 / 01期

基金：

英国科研创新办公室;

关键词：

ARDS; COVID-19; critical care; pneumonia; HEALTH; DYSPHAGIA;

D O I：

10.1136/bmjresp-2023-001647

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

ObjectiveIdentify prevalence of self-reported swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19. DesignMulticentre prospective observational cohort study using questionnaire data at visit 1 (2-7 months post discharge) and visit 2 (10-14 months post discharge) from hospitalised patients in the UK. Lasso logistic regression analysis was undertaken to identify associations. Setting64 UK acute hospital Trusts. ParticipantsAdults aged >18 years, discharged from an admissions unit or ward at a UK hospital with COVID-19. Main outcome measuresSelf-reported swallow, communication, voice and cognitive compromise. ResultsCompromised swallowing post intensive care unit (post-ICU) admission was reported in 20% (188/955); 60% with swallow problems received invasive mechanical ventilation and were more likely to have undergone proning (p=0.039). Voice problems were reported in 34% (319/946) post-ICU admission who were more likely to have received invasive (p<0.001) or non-invasive ventilation (p=0.001) and to have been proned (p<0.001). Communication compromise was reported in 23% (527/2275) univariable analysis identified associations with younger age (p<0.001), female sex (p<0.001), social deprivation (p<0.001) and being a healthcare worker (p=0.010). Cognitive issues were reported by 70% (1598/2275), consistent at both visits, at visit 1 respondents were more likely to have higher baseline comorbidities and at visit 2 were associated with greater social deprivation (p<0.001). ConclusionSwallow, communication, voice and cognitive problems were prevalent post hospitalisation for COVID-19, alongside whole system compromise including reduced mobility and overall health scores. Research and testing of rehabilitation interventions are required at pace to explore these issues.

引用

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