Targeting integrins in drug-resistant acute myeloid leukaemia

被引：12

作者：

Ogana, Heather A. ^{[1
]}

Hurwitz, Samantha ^{[1
]}

Wei, Nathan ^{[1
]}

Lee, Eliana ^{[1
]}

Morris, Kayla ^{[1
]}

Parikh, Karina ^{[1
]}

Kim, Yong-Mi ^{[1
]}

机构：

[1] Univ Southern Calif, Childrens Hosp Los Angeles, Keck Sch Med, Dept Pediat,Div Hematol & Oncol,Canc & Blood Dis I, Los Angeles, CA 90007 USA

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2024年 / 181卷 / 02期

基金：

美国国家卫生研究院;

关键词：

acute myeloid leukaemia; bone marrow microenvironment; cell adhesion molecules; cell adhesion-mediated chemoresistance; integrins; leukaemia stem cells; therapy; NEWLY-DIAGNOSED GLIOBLASTOMA; EMD; 525797; DI17E6; MONOCLONAL-ANTIBODY; OPEN-LABEL; PHASE-II; STANDARD TREATMENT; CELL-MIGRATION; CONCISE GUIDE; E-SELECTIN; CANCER;

D O I：

10.1111/bph.16149

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Acute myeloid leukaemia (AML) continues to have a poor prognosis, warranting new therapeutic strategies. The bone marrow (BM) microenvironment consists of niches that interact with not only normal haematopoietic stem cells (HSC) but also leukaemia cells like AML. There are many adhesion molecules in the BM microenvironment; therein, integrins have been of central interest. AML cells express integrins that bind to ligands in the microenvironment, enabling adhesion of leukaemia cells in the microenvironment, thereby initiating intracellular signalling pathways that are associated with cell migration, cell proliferation, survival, and drug resistance that has been described to mediate cell adhesion-mediated drug resistance (CAM-DR). Identifying and targeting integrins in AML to interrupt interactions with the microenvironment have been pursued as a strategy to overcome CAM-DR. Here, we focus on the BM microenvironment and review the role of integrins in CAM-DR of AML and discuss integrin-targeting strategies.

引用

页码：295 / 316

页数：22

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