Metabolic perspective of astrocyte dysfunction in Alzheimer's disease and type 2 diabetes brains

被引：28
作者：
Shen, Zheng [1 ]
Li, Zheng-Yang [1 ]
Yu, Meng-Ting [1 ]
Tan, Kai-Leng [2 ]
Chen, Si [1 ]
机构：
[1] Zunyi Med Univ, Zhuhai Campus, Zhuhai 519041, Guangdong, Peoples R China
[2] Guangdong Univ Technol, Inst Biomed & Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 158卷
基金：
中国国家自然科学基金;
关键词：
Alzheimer?s disease; Type; 2; diabetes; Astrocyte; Metabolism; Metabolic disorder; COGNITIVE IMPAIRMENT; MOUSE MODEL; GLUTAMATE; RECEPTOR; RISK; MITOCHONDRIA; EXPRESSION; PLASTICITY; PATHOLOGY; NEUROINFLAMMATION;
D O I：
10.1016/j.biopha.2022.114206
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The term type III diabetes (T3DM) has been proposed for Alzheimer's disease (AD) due to the shared molecular and cellular features between type 2 diabetes (T2DM) and insulin resistance-associated memory deficits and cognitive decline in elderly individuals. Astrocytes elicit neuroprotective or deleterious effects in AD progression and severity. Patients with T2DM are at a high risk of cognitive impairment, and targeting astrocytes might be promising in alleviating neurodegeneration in the diabetic brain. Recent studies focusing on cell-specific ac-tivities in the brain have revealed the important role of astrocytes in brain metabolism (e.g., glucose metabolism, lipid metabolism), neurovascular coupling, synapses, and synaptic plasticity. In this review, we discuss how astrocytes and their dysfunction result in multiple pathological and clinical features of AD and T2DM from a metabolic perspective and the potential comorbid mechanism in these two diseases from the perspective of astrocytes.
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页数：10
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