Maturation of large-scale brain systems over the first month of life

被引：17

作者：

Nielsen, Ashley N. ^{[1
]}

Kaplan, Sydney ^{[1
]}

Meyer, Dominique ^{[1
]}

Alexopoulos, Dimitrios ^{[1
]}

Kenley, Jeanette K. ^{[1
]}

Smyser, Tara A. ^{[2
]}

Wakschlag, Lauren S. ^{[3
,4
,5
]}

Norton, Elizabeth S. ^{[3
,4
,6
]}

Raghuraman, Nandini ^{[7
]}

Warner, Barbara B. ^{[8
]}

Shimony, Joshua S. ^{[9
]}

Luby, Joan L. ^{[2
]}

Neil, Jeffery J. ^{[1
,9
]}

Petersen, Steven E. ^{[1
]}

Barch, Deanna M. ^{[2
,9
,10
]}

Rogers, Cynthia E. ^{[6
,9
]}

Sylvester, Chad M. ^{[2
]}

Smyser, Christopher D. ^{[1
,8
]}

机构：

[1] Washington Univ, Dept Neurol, 660 S Euclid Ave, St Louis, MO 63110 USA

[2] Washington Univ, Dept Psychiat, 660 S Euclid Ave, St Louis, MO 63110 USA

[3] Northwestern Univ, Inst Innovat & Dev Sci, 420 E Super, Chicago, IL 60611 USA

[4] Northwestern Univ, Dept Med Social Sci, 420 E Super, Chicago, IL 60611 USA

[5] Northwestern Univ, Feinberg Sch Med, 420 E Super, Chicago, IL 60611 USA

[6] Northwestern Univ, Dept Commun Sci & Disorders, 420 E Super, Chicago, IL 60611 USA

[7] Washington Univ, Dept Obstet & Gynecol, 660 S Euclid Ave, St Louis, MO 63110 USA

[8] Washington Univ, Dept Pediat, 660 S Euclid Ave, St Louis, MO 63110 USA

[9] Washington Univ, Dept Radiol, 660 S Euclid Ave, St Louis, MO 63110 USA

[10] Washington Univ, Dept Psychol & Brain Sci, 660 S Euclid Ave, St Louis, MO 63110 USA

来源：

CEREBRAL CORTEX | 2023年 / 33卷 / 06期

关键词：

infant; functional connectivity; fMRI; machine learning; development; RESTING-STATE NETWORKS; FUNCTIONAL CONNECTIVITY; SENSITIVE PERIODS; CINGULATE CORTEX; MOTION ARTIFACT; PATTERNS; PREDICTION; MATURITY; CHARACTERIZE; ORGANIZATION;

D O I：

10.1093/cercor/bhac242

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The period immediately after birth is a critical developmental window, capturing rapid maturation of brain structure and a child's earliest experiences. Large-scale brain systems are present at delivery, but how these brain systems mature during this narrow window (i.e. first weeks of life) marked by heightened neuroplasticity remains uncharted. Using multivariate pattern classification techniques and functional connectivity magnetic resonance imaging, we detected robust differences in brain systems related to age in newborns (n = 262; R-2 = 0.51). Development over the first month of life occurred brain-wide, but differed and was more pronounced in brain systems previously characterized as developing early (i.e. sensorimotor networks) than in those characterized as developing late (i.e. association networks). The cingulo-opercular network was the only exception to this organizing principle, illuminating its early role in brain development. This study represents a step towards a normative brain "growth curve" that could be used to identify atypical brain maturation in infancy.

引用

页码：2788 / 2803

页数：16