Neuroprotective Activity of Olea Europaea and Malus Domestica in Stroke Model of Albino Rat

Stroke is the foremost cause of demise and disability globally. Nevertheless, treatment choices are still inadequate, despite decades of research. The study aimed to assess the neuroprotective effect of Olea europaea (extra virgin olive oil) (EVOE) and Malus domestica (apple cider vinegar) (MD) in the albino rat model of stroke. Their effect on motor and sensory functions (Locomotor asymmetry, forepaw dexterity, contralateral side injury, memory issues, and unilateral deficiency) was measured by cylinder test, pasta test, ladder rung walking test, Morris water maze test, and pole test, respectively. After 21 days of prophylactic dosing, the middle cerebral artery occlusion procedure induced the stroke. After the execution of the animals, 2,3,5 triphenyl tetrazolium chloride (TTC) was used to dye slices of the brain to measure the size of cerebral infarction. EVOE (0.75ml/kg/day) and MD (5ml/kg/day) alone have shown significant neuroprotective potential by improving the findings of the ladder rung walking test (P value < 0.05), pasta test (P value < 0.05), and cylinder test (P value < 0.05) to those fed with the standard dose of Piracetam (250 mg/kg/day). The rats who received EVOE (0.75ml/kg/day) and MD (5ml/kg/day) required less percentage time to reach the hidden maze when compared to rats of the group receiving the standard treatment of Piracetam (P value < 0.05). In the Pole test, mobility duration was significantly reduced by EVOE and MD compared to the treated control group (P value < 0.05). Histopathology showed likewise a significant effect of EVOE and MD on the ischemic part. In conclusion, EVOE and MD have exhibited noteworthy neuroprotective effects.