Precision medicine in oncology

被引:0
作者
Mack, Elisabeth [1 ]
机构
[1] Philipps Univ Marburg, Klin Hamatol Onkol & Immunol, Univ Klinikum Giessen & Marburg GmbH, Marburg, Germany
来源
INNERE MEDIZIN | 2024年 / 65卷 / 03期
关键词
Molecular tumor board; Personalized medicine; Molecular targeted therapy; High-throughput sequencing; Tumor biomarkers; TUMORS;
D O I
10.1007/s00108-023-01614-x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Personalized oncology according to current practice is primarily based on tumor biology, which is translated into genomic biomarkers. Mutations in oncogenes and tumor suppressor genes are targeted by rationally designed drugs and, conversely, are used to inform tailored treatment strategies. Faster and cheaper technologies for DNA sequencing enable genomic medicine in a clinical routine setting. Genomic features, tumor biology and clinical implications are integrated into individual therapy recommendations by molecular tumor boards, which have been established at many cancer centers in Germany and worldwide throughout recent years. This article discusses the promises and limitations of genomics-centered precision oncology and highlights future avenues and alternative approaches to individualize cancer treatment.
引用
收藏
页码:194 / 201
页数:8
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