Multi-thermo responsive double network composite hydrogel for 3D printing medical hydrogel mask

3D printing of multifunctional hydrogels offers great opportunities for developing innovative biomedical technologies as it can provide custom-designed shapes and structures conformal to arbitrary contours. There have been significant improvements of the 3D printing techniques, but the available printable hydro -gel materials limit the progress. Here, we investigated the use of a poloxamer diacrylate (Pluronic P123) to augment the thermo-responsive network composed of poly(N-isopropylacrylamide) and develop a multi-thermoresponsive hydrogel for photopolymerization 3D printing. The hydrogel precursor resin was synthesised to be printable with high-fidelity of fine structures and once cured can form a robust thermo-responsive hydrogel. By utilizing N-isopropyl acrylamide monomer and a Pluronic P123 diacrylate crosslinker as 2 separate thermo-responsive components it was found that the final hydrogel displayed 2 distinct lower critical solution temperature (LCST) switches. This enables the loading of hydrophilic drugs at fridge temperature and improving the strength of the hydrogel at room temperature while still maintain-ing a drug release at body temperature. The thermo-responsive material properties of this multifunctional hydrogel material system were investigated, showing a significant promise as a medical hydrogel mask. Furthermore, it is demonstrated that it can be printed in sizes large enough to fit and adhere to a human face at 1:1 scale with high dimensional accuracy, as well as its ability to load with hydrophilic drugs.(c) 2023 Elsevier Inc. All rights reserved.