Wnt3a is a promising target in colorectal cancer

被引：8
作者：
Tufail, Muhammad [1 ]
Wu, Changxin [1 ]
机构：
[1] Shanxi Univ, Inst Biomed Sci, Taiyuan 030006, Peoples R China
来源：
MEDICAL ONCOLOGY | 2023年 / 40卷 / 03期
基金：
英国科研创新办公室;
关键词：
Wnt pathway; Wnt3a; Colorectal cancer; Chemoresistance; Angiogenesis; EPITHELIAL-MESENCHYMAL TRANSITION; PROSTATE-CANCER; ANGIOGENESIS; BEVACIZUMAB; GROWTH; INHIBITION; EXPRESSION; PATHWAY; COMBINATION; PROGRESSION;
D O I：
10.1007/s12032-023-01958-2
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Most colorectal cancers (CRC) are associated with activated Wnt signaling, making it the fourth most prevalent type of cancer globally. To function properly, the Wnt signaling pathway requires secreted glycoproteins known as Wnt ligands (Wnts). Humans have 19 Wnts, which suggest a complicated signaling and biological process, and we still know little about their functions in developing CRC. This review aims to describe the canonical Wnt signaling in CRC, particularly the Wnt3a expression pattern, and their association with the angiogenesis and progression of CRC. This review also sheds light on the inhibition of Wnt3a signaling in CRC. Despite some obstacles, a thorough understanding of Wnts is essential for effectively managing CRC.
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页数：12
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