SPOOC (Sensor for Periodic Observation of Choline): An Integrated Lab-on-a-Spoon Platform for At-Home Quantification of Choline in Infant Formula

被引：13
作者：
Al-Shami, Abdulrahman [1 ]
Amirghasemi, Farbod [1 ]
Soleimani, Ali [1 ]
Nejad, Sina Khazaee [1 ]
Ong, Victor [1 ]
Berkmen, Alara [1 ]
Ainla, Alar [2 ]
Mousavi, Maral P. S. [1 ]
机构：
[1] Univ Southern Calif, Alfred E Mann Dept Biomed Engn, 1042 Downey Way, Los Angeles, CA 90089 USA
[2] Int Iberian Nanotechnol Lab, P-4715330 Braga, Portugal
来源：
SMALL | 2024年 / 20卷 / 31期
关键词：
at-home test; choline; ion-selective electrode (ISE); ionic liquid reference; infant formula; infant health; lab-on-a-spoon; laser-induced graphene (LIG); potentiometric sensor; solid contact; ION-SELECTIVE ELECTRODES; DIETARY REQUIREMENTS; GRAPHENE; BIOSENSOR; CHROMATOGRAPHY; CONDUCTIVITY; STABILITY; SAMPLE; MILK;
D O I：
10.1002/smll.202311745
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Choline is an essential micronutrient for infants' brain development and health. To ensure that infants receive the needed daily dose of choline, the U.S. Food and Drug Administration (FDA) has set requirements for choline levels in commercialized infant formulas. Unfortunately, not all families can access well-regulated formulas, leading to potential inadequacies in choline intake. Economic constraints or difficulties in obtaining formulas, exacerbated by situations like COVID-19, prompt families to stretch formulas. Accurate measurement of choline in infant formulas becomes imperative to guarantee that infants receive the necessary nutritional support. Yet, accessible tools for this purpose are lacking. An innovative integrated sensor for the periodic observation of choline (SPOOC) designed for at-home quantification of choline in infants' formulas and milk powders is reported. This system is composed of a choline potentiometric sensor and ionic-liquid reference electrode developed on laser-induced graphene (LIG) and integrated into a spoon-like device. SPOOC includes a micro-potentiometer that conducts the measurements and transmits results wirelessly to parents' mobile devices. SPOOC demonstrated rapid and accurate assessment of choline levels directly in pre-consuming infant formulas without any sample treatment. This work empowers parents with a user-friendly tool for choline monitoring promoting informed nutritional decision-making in the care of infants. SPOOC, a fast, accurate, and wireless device, quantifies choline in infants' formulas in home settings. It utilizes laser-induced graphene as a platform for choline potentiometric detection and features a detachable potentiometric device that wirelessly transmits data to nearby smartphones. This device assists parents in ensuring infants receive sufficient choline, promoting better neural and muscular health. image
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页数：16
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