Brain metastases and next-generation anticancer therapies: a survival guide for clinicians

被引：3

作者：

Dipasquale, Angelo ^{[1
]}

Barigazzi, Chiara ^{[1
,2
]}

Losurdo, Agnese ^{[1
,2
]}

Persico, Pasquale ^{[1
,2
]}

Di Muzio, Antonio ^{[1
,2
]}

Navarria, Piera ^{[3
]}

Pessina, Federico ^{[2
,4
]}

Bent, Martin van den ^{[5
]}

Santoro, Armando ^{[1
,2
]}

Simonelli, Matteo ^{[1
,2
,6
]}

机构：

[1] IRCCS Humanitas Res Hosp, Med Oncol & Hematol Unit, Milan, Rozzano, Italy

[2] Humanitas Univ, Dept Biomed Sci, Milan, Pieve Emanuele, Italy

[3] IRCCS Humanitas Res Hosp, Dept Radiotherapy & Radiosurg, Milan, Rozzano, Italy

[4] IRCCS Humanitas Res Hosp, Dept Neurosurg, Milan, Rozzano, Italy

[5] Erasmus MC Canc Inst, Brain Tumor Ctr, Rotterdam, Netherlands

[6] Humanitas Univ, Humanitas Res Hosp IRCCS, Humanitas Canc Ctr, Dept Biomed Sci, Milan, Rozzano, Italy

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2024年 / 194卷

关键词：

Neuro-oncology; Brain tumors; Brain metastases; Targeted therapies; Immunotherapy; CELL LUNG-CANCER; NIVOLUMAB PLUS IPILIMUMAB; NERVOUS-SYSTEM METASTASES; OPEN-LABEL; BREAST-CANCER; INTRACRANIAL EFFICACY; PHASE-II; PRIMARY TUMORS; NSCLC; TRASTUZUMAB;

D O I：

10.1016/j.critrevonc.2023.104239

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Historically, patients with brain metastases (BMs) have been characterized by few systemic treatment options and poor prognosis. The recent introduction of next-generation anticancer therapies such as molecular targeted agents and immunotherapy have revolutionized the clinical decision-making process of this sub-population, posing new challenges to physicians. In this review, current evidence for the use of checkpoint inhibitors and targeted therapies in patients with BMs are discussed, with a focus on lung cancer, breast cancer, melanoma and renal cell carcinoma, providing suggestions and potential workflows for daily clinical practice. Several other ongoing and future challenges, such as clinical trials design, ways to improve CNS penetration of novel drugs and unique molecular characteristics of BMs, are also discussed. The aim is producing an updated and easy-to-read guide for physicians, to improve decision-making in clinical practice.

引用

页数：12

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