Genetic and epigenetic determinants of non-alcoholic fatty liver disease (NAFLD) in lean individuals: a systematic review

被引:8
作者
Njei, Basile [1 ,7 ]
Al-Ajlouni, Yazan A. [2 ]
Ugewndum, Derek [3 ]
Abdu, Manasik [4 ]
Forjindam, Anim [5 ]
Mohamed, Mouhand F. [6 ]
机构
[1] Yale Sch Med, Int Med Program, Sect Digest Dis, New Haven, CT USA
[2] New York Med Coll, Sch Med, Valhalla, NY USA
[3] Richmond Univ Med Ctr, Staten Isl, NY USA
[4] SUNY Buffalo, Dept Internal Med, Catholic Hlth Syst, Buffalo, NY USA
[5] Case Western Reserve Univ, Dept Physiol & Biophys, Med Physiol Program, Sch Med, Cleveland, OH USA
[6] Brown Univ, Dept Med, Providence, RI USA
[7] Yale Sch Med, Int Med Program, Sect Digest Dis, Wing Bldg 35A,Fl 2,Rm 210, West Haven, CT 06516 USA
关键词
Non-alcoholic fatty liver disease (NAFLD); lean individuals; genetics; epigenetics; systematic review; CONFERS SUSCEPTIBILITY; RISK; ASSOCIATION; VARIANT;
D O I
10.21037/tgh-23-31
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: Non-alcoholic fatty liver disease (NAFLD) is common in obese individuals, but its occurrence in lean individuals and the underlying mechanisms are not well understood. This study aimed to systematically review the literature on the genetic and epigenetic factors influencing NAFLD in lean individuals.Methods: A comprehensive search was conducted on April 2nd, 2023, in seven databases using specific criteria. Only peer-reviewed studies in English, focusing on genetic or epigenetic effects on NAFLD in lean individuals, were included for qualitative synthesis. The Newcastle Ottawa Scale (NOS) was used for quality assessment. This study is registered with PROSPERO (CRD42023413809).Results: Following PRISMA guidelines, 18 studies were included in this review. The studies were conducted globally, with varying sample sizes and study designs. The NOS quality assessment revealed a moderate overall quality with variations in risk of bias and limitations in comparability and ascertainments of exposure among contributing studies. Genetic determinants related to lipid metabolism, inflammation, and oxidative stress pathways were identified, including PNPLA3 and TM6SF2 gene variants associated with increased NAFLD risk in lean individuals. Epigenetic modifications, particularly depletion of histone variants, were also implicated. However, some studies found no significant associations between genetic or clinical characteristics and lean NAFLD. Less frequent genetic risk factors, such as CETP and APOC3 gene variants, were reported.Conclusions: This systematic review underscores the importance of investigating genetic and epigenetic factors in lean NAFLD. The findings highlight the role of PNPLA3 and TM6SF2 gene variants and suggest potential epigenetic contributions. Further research is needed to fully understand the genetic and epigenetic mechanisms underlying NAFLD in lean individuals.
引用
收藏
页数:18
相关论文
共 50 条
[31]   Prevalence of Non-alcoholic Fatty Liver Disease (NAFLD) in Saudi Arabia: Systematic Review and Meta-analysis [J].
Alenezi, Yusef M. ;
Harris, Rebecca ;
Morling, Joanne ;
Card, Tim .
CUREUS JOURNAL OF MEDICAL SCIENCE, 2023, 15 (06)
[32]   Differences in the genetic backgrounds of patients with alcoholic liver disease and non-alcoholic fatty liver disease [J].
Yamamoto, Kuniko ;
Kogiso, Tomomi ;
Taniai, Makiko ;
Hashimoto, Etsuko ;
Tokushige, Katsutoshi .
JGH OPEN, 2019, 3 (01) :17-24
[33]   Clinical guidelines of non-alcoholic fatty liver disease: A systematic review [J].
Jin-Zhou Zhu ;
Kelseanna Hollis-Hansen ;
Xing-Yong Wan ;
Su-Juan Fei ;
Xun-Lei Pang ;
Fan-Dong Meng ;
Chao-Hui Yu ;
You-Ming Li .
World Journal of Gastroenterology, 2016, 22 (36) :8226-8233
[34]   Clinical guidelines of non-alcoholic fatty liver disease: A systematic review [J].
Zhu, Jin-Zhou ;
Hollis-Hansen, Kelseanna ;
Wan, Xing-Yong ;
Fei, Su-Juan ;
Pang, Xun-Lei ;
Meng, Fan-Dong ;
Yu, Chao-Hui ;
Li, You-Ming .
WORLD JOURNAL OF GASTROENTEROLOGY, 2016, 22 (36) :8226-8233
[35]   Clinical features and metabolic complications for non-alcoholic fatty liver disease (NAFLD) in youth with obesity [J].
Barbieri, Emiliano ;
Santoro, Nicola ;
Umano, Giuseppina Rosaria .
FRONTIERS IN ENDOCRINOLOGY, 2023, 14
[36]   Navigating the Link Between Non-alcoholic Fatty Liver Disease/ Non-alcoholic Steatohepatitis and Cardiometabolic Syndrome [J].
Gato, Sheila ;
Garcia-Fernandez, Vanessa ;
Gil-Gomez, Antonio ;
Rojas, Angela ;
Montero-Vallejo, Rocko ;
Munoz-Hernandez, Rocko ;
Romero-Gomez, Manuel .
EUROPEAN CARDIOLOGY REVIEW, 2024, 19
[37]   Non-Alcoholic Fatty Liver Disease: Metabolic, Genetic, Epigenetic and Environmental Risk Factors [J].
Juanola, Oriol ;
Martinez-Lopez, Sebastian ;
Frances, Ruben ;
Gomez-Hurtado, Isabel .
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2021, 18 (10)
[38]   The potential association between periodontitis and non-alcoholic fatty liver disease: a systematic review [J].
Mohammad Sultan Alakhali ;
Sadeq Ali Al-Maweri ;
Hashem Motahir Al-Shamiri ;
Khaled Al-haddad ;
Esam Halboub .
Clinical Oral Investigations, 2018, 22 :2965-2974
[39]   The potential association between periodontitis and non-alcoholic fatty liver disease: a systematic review [J].
Alakhali, Mohammad Sultan ;
Al-Maweri, Sadeq Ali ;
Al-Shamiri, Hashem Motahir ;
Al-haddad, Khaled ;
Halboub, Esam .
CLINICAL ORAL INVESTIGATIONS, 2018, 22 (09) :2965-2974
[40]   Lean Indian patients with non-alcoholic fatty liver disease (NAFLD) have less metabolic risk factors but similar liver disease severity as non-lean patients with NAFLD [J].
De, Arka ;
Mehta, Manu ;
Singh, Priya ;
Bhagat, Naveen ;
Mitra, Suvradeep ;
Das, Ashim ;
Duseja, Ajay .
INTERNATIONAL JOURNAL OF OBESITY, 2023, 47 (10) :986-992