Application of peripherally inserted central catheter in immune tolerance induction treatment of children with hemophilia A and accompanying inhibitors in China

被引：0
作者：
Wang, Chunli [1 ,2 ]
Liu, Guoqing [2 ,3 ,4 ,5 ,6 ]
Ding, Yaguang [1 ,2 ]
Li, Zekun [2 ,3 ,4 ,5 ,6 ]
Zhen, Yingzi [1 ,2 ]
Cui, Jie [1 ,2 ]
Yao, Wanru [2 ,3 ,4 ,5 ,6 ]
Di, Ai [2 ,3 ,4 ,5 ,6 ]
Huang, Kun [2 ,3 ,4 ,5 ,6 ]
Feng, Ping [1 ,2 ]
Wu, Runhui [2 ,3 ,4 ,5 ,6 ]
机构：
[1] Capital Med Univ, Beijing Childrens Hosp, Nursing Dept, Beijing, Peoples R China
[2] Natl Ctr Childrens Hlth, Beijing, Peoples R China
[3] Hematol Ctr, Beijing Key Lab Pediat Hematol Oncol, Beijing, Peoples R China
[4] Capital Med Univ, Natl Key Discipline Pediat, Beijing, Peoples R China
[5] Minist Educ, Key Lab Major Dis Children, Beijing, Peoples R China
[6] Capital Med Univ, Beijing Childrens Hosp, Dept Hematol Ctr 2, Haemophilia Comprehens Care Ctr, Beijing, Peoples R China
来源：
HEMATOLOGY | 2023年 / 28卷 / 01期
关键词：
Hemophilia; PICC; inhibitors; ITI; children; China; FVIII; home therapy; VENOUS ACCESS DEVICES; COMPLICATIONS; IMPACT;
D O I：
10.1080/16078454.2023.2250601
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: To explore the feasibility, safety and cost effectiveness of the use of peripherally inserted central catheter (PICC) in children with hemophilia A and inhibitors who underwent ITI treatment. Method: This retrospective cohort study evaluated the effect of PICC placement and ITI on bleeding rates, costs, and parents' satisfaction before and within 6 months after PICC placement in children with hemophilia A and inhibitors. Results: A total of 20 children with hemophilia A and high-titer inhibitors were included, with a success rate for PICC placement of 100%, at a cost of < yen > 6730.50. Parents' satisfaction with PICC was 100%, and the total length of catheter indwelling was 6055 days. In terms of curative effect, the success rate of ITI treatment was 75%, and the annualized bleeding rate was decreased from 10.90 +/- 12.16 times before placement to 2.10 +/- 3.32 times ( p < 0.05). The transportation expense for children and their parents to the clinic decreased from < yen > 20,920 +/- 32,274.57 before catheter placement to < yen > 2915 +/- 2195.99 (p < 0.05). Time of children missed school and their parents missed work decreased from 10.85 +/- 22.36 days to 1.90 +/- 3.58 (p < 0.05) days and 40.33 +/- 46.11 days to 3.83 +/- 7.11 days ( p < 0.05), respectively. Conclusion: The use of PICC for ITI treatment in children with hemophilia A and accompanying inhibitors in developing countries (e.g. China) can ensure the effect of ITI, reducing expense and improving the quality of life without obvious side effects.
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