COVID-19 severity and cardiovascular outcomes in SARS-CoV-2-infected patients with cancer and cardiovascular disease

被引：0

作者：

Moey, Melissa Y. Y. ^{[1
]}

Hennessy, Cassandra ^{[2
]}

French, Benjamin ^{[2
]}

Warner, Jeremy L. ^{[3
,4
,5
]}

Tucker, Matthew D. ^{[4
]}

Hausrath, Daniel J. ^{[4
]}

Shah, Dimpy P. ^{[6
]}

DeCara, Jeanne M. ^{[7
]}

Bakouny, Ziad ^{[8
]}

Labaki, Chris ^{[8
]}

Choueiri, Toni K. ^{[8
]}

Dent, Susan ^{[9
]}

Akhter, Nausheen ^{[10
]}

Ismail-Khan, Roohi ^{[11
,12
]}

Tachiki, Lisa ^{[13
,47
]}

Slosky, David ^{[14
]}

Polonsky, Tamar S. ^{[15
]}

Awosika, Joy A. ^{[16
]}

Crago, Audrey ^{[16
]}

Wise-Draper, Trisha ^{[16
]}

Balanchivadze, Nino ^{[17
]}

Hwang, Clara ^{[17
]}

Fecher, Leslie A. ^{[18
]}

Gomez, Cyndi Gonzalez ^{[18
]}

Hayes-Lattin, Brandon ^{[19
]}

Glover, Michael J. ^{[20
]}

Shah, Sumit A. ^{[20
]}

Gopalakrishnan, Dharmesh ^{[21
]}

Griffiths, Elizabeth A. ^{[21
]}

Kwon, Daniel H. ^{[22
]}

Koshkin, Vadim S. ^{[22
]}

Mahmood, Sana ^{[23
]}

Bashir, Babar ^{[23
]}

Nonato, Taylor ^{[24
]}

Razavi, Pedram ^{[24
]}

McKay, Rana R.

Nagaraj, Gayathri ^{[25
]}

Oligino, Eric ^{[26
]}

Puc, Matthew ^{[27
]}

Tregubenko, Polina ^{[28
]}

Wulff-Burchfield, Elizabeth M. ^{[28
]}

Xie, Zhuoer ^{[29
]}

Halfdanarson, Thorvardur R. ^{[29
]}

Farmakiotis, Dimitrios ^{[30
,31
]}

Klein, Elizabeth J. ^{[30
,31
]}

Robilotti, Elizabeth V. ^{[32
]}

Riely, Gregory J. ^{[32
]}

Durand, Jean-Bernard ^{[33
]}

Hayek, Salim S. ^{[34
]}

Kondapalli, Lavanya ^{[35
]}

机构：

[1] East Carolina Univ, Vidant Med Ctr, Dept Cardiovasc Dis, Greenville, NC USA

[2] Vanderbilt Univ, Med Ctr, Dept Biostat, Nashville, TN USA

[3] Vanderbilt Univ, Vanderbilt Ingram Canc Ctr, Med Ctr, Nashville, TN USA

[4] Vanderbilt Univ, Dept Med, Div Hematol Oncol, Nashville, TN USA

[5] Vanderbilt Univ, Dept Biomed Informat, Nashville, TN USA

[6] UTHlth San Antonio MD Anderson, Mays Canc Ctr, San Antonio, TX USA

[7] Univ Chicago, Med Ctr, Sect Cardiol, Chicago, IL USA

[8] Dana Farber Canc Inst, Boston, MA 02215 USA

[9] Duke Univ, Med Ctr, Duke Canc Inst, Durham, NC USA

[10] Northwestern Univ, Feinberg Sch Med, Div Cardiol, Chicago, IL USA

[11] Univ S Florida, Morsani Coll Med, Cardiooncol Program, Div Cardiovasc Med, Tampa, FL USA

[12] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA

[13] Univ Washington, Seattle, WA USA

[14] Vanderbilt Univ, Dept Med, Cardiooncol Program, Med Ctr, Nashville, TN USA

[15] Univ Chicago, Dept Med, Chicago, IL USA

[16] Univ Cincinnati, Canc Ctr, Cincinnati, OH USA

[17] Henry Ford Hosp, Henry Ford Canc Inst, Detroit, MI USA

[18] Univ Michigan, Rogel Canc Ctr, Ann Arbor, MI USA

[19] Oregon Hlth & Sci Univ, Knight Canc Inst, Div Hematol & Med Oncol, Portland, OR USA

[20] Stanford Univ, Stanford Canc Inst, Stanford, CA USA

[21] Roswell Pk Comprehens Canc Ctr, Dept Med, Buffalo, NY USA

[22] Univ Calif San Francisco, UCSF Helen Diller Family Comprehens Canc Ctr, San Francisco, CA USA

[23] Thomas Jefferson Univ, Sidney Kimmel Canc Ctr, Philadelphia, PA USA

[24] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA USA

[25] Loma Linda Univ, Div Med Oncol & Hematol, Loma Linda, CA USA

[26] Hartford HealthCare Canc, Cardiooncol, Hartford, CT USA

[27] Virtua Hlth, Marlton, NJ USA

[28] Univ Kansas Hlth Syst, Kansas City, KS USA

[29] Mayo Clin, Rochester, MN USA

[30] Brown Univ, Providence, RI USA

[31] Lifespan Canc Inst, Providence, RI USA

[32] Mem Sloan Kettering Canc Ctr, New York, NY USA

[33] MD Anderson Canc Ctr, Houston, TX USA

[34] Univ Michigan, Dept Internal Med, Div Cardiol, Ann Arbor, MI USA

[35] Univ Colorado Anschutz Med Campus, Dept Med, Div Cardiol, Aurora, CO USA

[36] Loyola Univ Med Ctr, Chicago, IL USA

[37] Emory Univ, Winship Canc Inst, Atlanta, GA USA

[38] Columbia Univ, Herbert Irving Comprehens Canc Ctr, New York, NY USA

[39] Northwest Med Specialties, Tacoma, WA USA

[40] Mt Auburn Hosp, Cambridge, MA USA

[41] St Elizabeth Healthcare, Edgewood, KY USA

[42] McGill Univ, Jewish Gen Hosp, Segal Canc Ctr, Montreal, PQ, Canada

[43] McGill Univ, Hlth Ctr, Montreal, PQ, Canada

[44] Inst Nacl Cancerol, Mexico City, Mexico

[45] Cleveland Clin, Cleveland, OH USA

[46] Brigham & Womens Hosp, Dana Farber Canc Inst, Cardiovasc Div, Boston, MA 02115 USA

[47] Fred Hutchinson Canc Res Ctr, Seattle, WA USA

来源：

TRANSLATIONAL ONCOLOGY | 2023年 / 34卷

关键词：

COVID-19; outcomes; Cardio-oncology; Cardiovascular disease; Cancer;

D O I：

10.1016/j.tranon.2023.101709

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Data regarding outcomes among patients with cancer and co-morbid cardiovascular disease (CVD)/ cardiovascular risk factors (CVRF) after SARS-CoV-2 infection are limited.Objectives: To compare Coronavirus disease 2019 (COVID-19) related complications among cancer patients with and without co-morbid CVD/CVRF.Methods: Retrospective cohort study of patients with cancer and laboratory-confirmed SARS-CoV-2, reported to the COVID-19 and Cancer Consortium (CCC19) registry from 03/17/2020 to 12/31/2021. CVD/CVRF was defined as established CVD or no established CVD, male & GE; 55 or female & GE; 60 years, and one additional CVRF. The primary endpoint was an ordinal COVID-19 severity outcome including need for hospitalization, supplemental oxygen, intensive care unit (ICU), mechanical ventilation, ICU or mechanical ventilation plus vasopressors, and death. Secondary endpoints included incident adverse CV events. Ordinal logistic regression models estimated associations of CVD/CVRF with COVID-19 severity. Effect modification by recent cancer therapy was evaluated.Results: Among 10,876 SARS-CoV-2 infected patients with cancer (median age 65 [IQR 54-74] years, 53% fe-male, 52% White), 6253 patients (57%) had co-morbid CVD/CVRF. Co-morbid CVD/CVRF was associated with higher COVID-19 severity (adjusted OR: 1.25 [95% CI 1.11-1.40]). Adverse CV events were significantly higher in patients with CVD/CVRF (all p<0.001). CVD/CVRF was associated with worse COVID-19 severity in patients who had not received recent cancer therapy, but not in those undergoing active cancer therapy (OR 1.51 [95% CI 1.31-1.74] vs. OR 1.04 [95% CI 0.90-1.20], pinteraction <0.001).Conclusions: Co-morbid CVD/CVRF is associated with higher COVID-19 severity among patients with cancer, particularly those not receiving active cancer therapy. While infrequent, COVID-19 related CV complications were higher in patients with comorbid CVD/CVRF. (COVID-19 and Cancer Consortium Registry [CCC19]; NCT04354701).

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