Nonthrombogenic Roles of the Left Atrial Appendage JACC Review Topic of the Week

被引：15

作者：

Alkhouli, Mohamad ^{[1
,6
]}

Di Biase, Luigi ^{[2
]}

Natale, Andrea ^{[3
]}

Rihal, Charanjit S. ^{[1
]}

Holmes, David R. ^{[1
]}

Asirvatham, Samuel ^{[1
]}

Bartus, Krzysztof ^{[4
]}

Lakkireddy, Dhanunjaya ^{[5
]}

Friedman, Paul A. ^{[1
]}

机构：

[1] Mayo Clin, Sch Med, Dept Cardiol, Rochester, MN 55905 USA

[2] Albert Einstein Coll Med, Montefiore Einstein Ctr Heart & Vasc Care, Montefiore Med Ctr, Bronx, NY USA

[3] Texas Cardiac Arrhythmia Inst, St Davids Med Ctr, Austin, TX USA

[4] Jagiellonian Univ, John Paul Hosp, Med Coll, Dept Cardiovasc Surg & Transplantol, Krakow, Poland

[5] Kansas City Heart Rhythm Inst, Overland Pk, KS USA

[6] Mayo Clin, Dept Cardiovasc Med, 200 First St SW, Rochester, MN 55905 USA

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2023年 / 81卷 / 11期

关键词：

KEY WORDS atrial fibrillation; hemodynamics; left atrial appendage; progenitor cells; ELECTRICAL ISOLATION; STEM-CELLS; EPICARDIAL TRANSPLANTATION; ACCESSORY APPENDAGES; NATRIURETIC-FACTOR; CATHETER ABLATION; FIBRILLATION; CLOSURE; SUPPORT; STROKE;

D O I：

10.1016/j.jacc.2023.01.017

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The atrial appendage (LAA) is a well-established source of cardioembolism in patients with atrial fibrillation. Therefore, research involving the LAA has largely focused on its thrombogenic attribute and the utility of its exclusion in stroke prevention. However, recent studies have highlighted several novel functions of the LAA that may have important therapeutic implications. In this paper, we provide a concise overview of the LAA anatomy and summarize the emerging data on its nonthrombogenic roles.(c) 2023 by the American College of Cardiology Foundation.

引用

页码：1063 / 1075

页数：13

共 69 条

[31] Left atrial accessory appendages, diverticula, and left-sided septal pouch in multi-slice computed tomography. Association with atrial fibrillation and cerebrovascular accidents [J].

Holda, Mateusz K. ;

Koziej, Mateusz ;

Wszolek, Karolina ;

Pawlik, Wieslaw ;

Krawczyk-Ozog, Agata ;

Sorysz, Danuta ;

Loboda, Piotr ;

Kuzma, Katarzyna ;

Kuniewicz, Marcin ;

Lelakowski, Jacek ;

Dudek, Dariusz ;

Klimek-Piotrowska, Wieslawa .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2017, 244 :163-168

[32]

Holmes David R Jr, 2020, Card Electrophysiol Clin, V12, P1, DOI [10.1016/j.ccep.2019.11.009, 10.1016/j.ccep.2019.11.009]

[33] Left Atrial Appendage Occlusion for The Unmet Clinical Needs of Stroke Prevention in Nonvalvular Atrial Fibrillation [J].

Holmes, David R., Jr. ;

Alkhouli, Mohamad ;

Reddy, Vivek .

MAYO CLINIC PROCEEDINGS, 2019, 94 (05) :864-874

[34] Improvement in left atrial strain among patients undergoing percutaneous left atrial appendage closure [J].

Ijuin, Shun ;

Hamadanchi, Ali ;

Haertel, Franz ;

Baez, Laura ;

Schulze, Paul Christian ;

Franz, Marcus ;

Moebius-Winkler, Sven .

JOURNAL OF CARDIOVASCULAR ECHOGRAPHY, 2020, 30 (01) :15-21

[35] The left atrial appendage: our most lethal human attachment! Surgical implications [J].

Johnson, WD ;

Ganjoo, AK ;

Stone, CD ;

Srivyas, RC ;

Howard, M .

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2000, 17 (06) :718-722

[36]

Kanmanthareddy Arun, 2014, Interv Cardiol Clin, V3, P191, DOI 10.1016/j.iccl.2013.11.002

[37]

Khabbaz K, 2020, CIRCULATION, V142, P504, DOI [10.1161/CIRCULATIONAHA.120.051365, DOI 10.1161/CIRCULATIONAHA.120.051365]

[38] Relationship between left atrial appendage morphology and stroke in patients with atrial fibrillation [J].

Khurram, Irfan M. ;

Dewire, Jane ;

Mager, Michael ;

Maqbool, Farhan ;

Zimmerman, Stefan L. ;

Zipunnikov, Vadim ;

Beinart, Roy ;

Marine, Joseph E. ;

Spragg, David D. ;

Berger, Ronald D. ;

Ashikaga, Hiroshi ;

Nazarian, Saman ;

Calkins, Hugh .

HEART RHYTHM, 2013, 10 (12) :1843-1849

[39] Predictors of Subsequent Heart Failure After Left Atrial Appendage Closure [J].

Kim, Dae-Young ;

Kim, Min Ji ;

Seo, Jiwon ;

Cho, Iksung ;

Shim, Chi Young ;

Hong, Geu-Ru ;

Kim, Jung-Sun ;

Ha, Jong-Won .

CIRCULATION JOURNAL, 2022, 86 (06) :1129-+

[40] The cardiac atrial appendage stem cell: a new and promising candidate for myocardial repair [J].

Koninckx, Remco ;

Daniels, Annick ;

Windmolders, Severina ;

Mees, Urbain ;

Macianskiene, Regina ;

Mubagwa, Kanigula ;

Steels, Paul ;

Jamaer, Luc ;

Dubois, Jasperina ;

Robic, Boris ;

Hendrikx, Marc ;

Rummens, Jean-Luc ;

Hensen, Karen .

CARDIOVASCULAR RESEARCH, 2013, 97 (03) :413-423

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