Correlation between C-reactive protein and postoperative mortality in patients undergoing hip fracture surgery: a meta-analysis

被引:9
作者
Chen, Bing-Kuan [1 ]
Liu, Yu-Cheng [2 ]
Chen, Chun-Ching [2 ]
Chen, Yu-Pin [3 ,4 ]
Kuo, Yi-Jie [3 ,4 ]
Huang, Shu-Wei [3 ]
机构
[1] Shuang Ho Hosp, Dept Gen Med, New Taipei, Taiwan
[2] Taipei Med Univ, Coll Med, Taipei, Taiwan
[3] Taipei Med Univ, Wan Fang Hosp, Dept Orthoped, 111,Sec 3,Xinglong Rd, Taipei 116, Taiwan
[4] Taipei Med Univ, Coll Med, Sch Med, Dept Orthopaed, Taipei, Taiwan
关键词
Hip fracture; Hip fracture surgery; C-reactive protein; Mortality; CARDIOVASCULAR RISK; SERUM-ALBUMIN; INFLAMMATION; PROGNOSIS; RANGE; DEATH; AGE;
D O I
10.1186/s13018-023-03516-y
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
BackgroundHip fracture is a common but devastating disease with a high mortality rate in the older adult population. C-reactive protein (CRP) is a predictor of the prognosis in many diseases, but its correlations with patient outcomes following hip fracture surgery remain unclear. In this meta-analysis, we investigated the correlation between perioperative CRP level and postoperative mortality in patients undergoing hip fracture surgery.MethodsPubMed, Embase, and Scopus were searched for relevant studies published before September 2022. Observational studies investigating the correlation between perioperative CRP level and postoperative mortality in patients with hip fracture were included. The differences in CRP levels between the survivors and nonsurvivors following hip fracture surgery were measured with mean differences (MDs) and 95% confidence intervals (CIs).ResultsFourteen prospective and retrospective cohort studies comprising 3986 patients with hip fracture were included in the meta-analysis. Both the preoperative and postoperative CRP levels were significantly higher in the death group than in the survival group when the follow-up duration was >= 6 months (MD: 0.67, 95% CI: 0.37-0.98, P < 0.0001; MD: 1.26, 95% CI: 0.87-1.65, P < 0.00001, respectively). Preoperative CRP levels were significantly higher in the death group than in the survival group when the follow-up duration was <= 30 days (MD: 1.49, 95% CI: 0.29-2.68; P = 0.01).ConclusionsBoth higher preoperative and postoperative CRP levels were correlated with higher risk of mortality following hip fracture surgery, suggesting the prognostic role of CRP. Further studies are warranted to confirm the ability of CRP to predict postoperative mortality in patients with hip fracture.
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页数:9
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