Comprehensive Overview of Diamide Derivatives Acting as Ryanodine Receptor Activators

被引：7
作者：
Du, Shaoqing [1 ]
Hu, Xueping [2 ]
机构：
[1] Shandong Univ, Cheeloo Coll Med, Sch Pharmaceut Sci, Dept Med Chem,Key Lab Chem Biol,Minist Educ, Jinan 250012, Shandong, Peoples R China
[2] Shandong Univ, Inst Mol Sci & Engn, Inst Frontier & Interdisciplinary Sci, Qingdao 266237, Peoples R China
来源：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2023年 / 71卷 / 08期
基金：
中国国家自然科学基金;
关键词：
diamide insecticides; ryanodine receptor activators; resistance; insecticidal activity; ACTIVITY-RELATIONSHIP SAR; ANTHRANILIC DIAMIDES; INSECTICIDAL ACTIVITY; BIOLOGICAL-ACTIVITIES; CRYSTAL-STRUCTURE; PYRAZOLE AMIDES; DESIGN; RESISTANCE; PYRIDYLPYRAZOLE; ANALOGS;
D O I：
10.1021/acs.jafc.2c08414
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
The world's hunger is continuously rising due to conflicts, climate change, pandemics (such as the recent COVID-19), and crop pests and diseases. It is widely accepted that zero hunger is impossible without using agrochemicals to control crop pests and diseases. Diamide insecticides are one of the widely used green insecticides developed in recent years and play important roles in controlling lepidopteran pests. Currently, eight diamine insecticides have been commercialized, which target the insect ryanodine receptors. This review summarizes the development and optimization processes of diamide derivatives acting as ryanodine receptor activators. The review also discusses pest resistance to diamide derivatives and possible solutions to overcome the limitations posed by the resistance. Thus, with reference to structural biology, this study provides an impetus for designing and developing diamide insecticides with improved insecticidal activities.
引用
收藏
页码：3620 / 3638
页数：19
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