Microbiology and immune mechanisms associated with male infertility

被引:13
作者
Chen, Jin [1 ]
Chen, Jinyu [2 ]
Fang, Yiwei [1 ]
Shen, Qiuzi [1 ]
Zhao, Kai [1 ]
Liu, Chunyan [1 ]
Zhang, Huiping [1 ]
机构
[1] Huazhong Univ Sci & Technol, Inst Reprod Hlth, Tongji Med Coll, Wuhan, Peoples R China
[2] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Urol, Wuhan, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
基金
国家重点研发计划;
关键词
microbiology; immune; infertility; varicocele; orchitis; prostatitis; oligospermia; PELVIC PAIN SYNDROME; EXPERIMENTAL AUTOIMMUNE PROSTATITIS; SEMINAL PLASMA; TESTICULAR INFLAMMATION; CHLAMYDIA-TRACHOMATIS; SEMEN CHARACTERISTICS; ANTISPERM ANTIBODIES; BIOFILM FORMATION; OXIDATIVE STRESS; MALE-FERTILITY;
D O I
10.3389/fimmu.2023.1139450
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Up to 50% of infertility is caused by the male side. Varicocele, orchitis, prostatitis, oligospermia, asthenospermia, and azoospermia are common causes of impaired male reproductive function and male infertility. In recent years, more and more studies have shown that microorganisms play an increasingly important role in the occurrence of these diseases. This review will discuss the microbiological changes associated with male infertility from the perspective of etiology, and how microorganisms affect the normal function of the male reproductive system through immune mechanisms. Linking male infertility with microbiome and immunomics can help us recognize the immune response under different disease states, providing more targeted immune target therapy for these diseases, and even the possibility of combined immunotherapy and microbial therapy for male infertility.
引用
收藏
页数:13
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