Impact of COVID-19 on pregnancy and fetal outcomes in women with multiple sclerosis

被引：1

作者：

Aprea, Maria Grazia ^{[1
]}

Schiavetti, Irene ^{[2
]}

Portaccio, Emilio ^{[1
]}

Ballerini, Chiara ^{[1
]}

Bonavita, Simona ^{[3
]}

Buscarinu, Maria ^{[4
]}

Calabrese, Massimiliano ^{[5
]}

Cavalla, Paola ^{[6
]}

Cellerino, Maria ^{[7
]}

Cordioli, Cinzia ^{[8
]}

Dattola, Vincenzo ^{[9
]}

De Biase, Stefano ^{[10
]}

De Meo, Ermelinda ^{[1
]}

Fantozzi, Roberta ^{[11
]}

Gallo, Antonio ^{[12
]}

Iasevoli, Luigi ^{[13
]}

Karabudak, Rana ^{[14
]}

Landi, Doriana ^{[15
]}

Lorefice, Lorena ^{[16
]}

Moiola, Lucia ^{[17
]}

Ragonese, Paolo ^{[18
]}

Ruscica, Francesca ^{[19
]}

Sen, Sedat ^{[20
]}

Sinisi, Leonardo ^{[21
]}

Signoriello, Elisabetta ^{[3
]}

Toscano, Simona ^{[22
,23
]}

Verrengia, Elena ^{[24
]}

Siva, Aksel ^{[25
]}

Masciulli, Camilla ^{[1
]}

Sormani, Maria Pia ^{[2
,26
,28
]}

Amato, Maria Pia ^{[1
,27
]}

机构：

[1] Univ Florence, Dept NEUROFARBA, Florence, Italy

[2] Univ Genoa, Dept Hlth Sci, Sect Biostat, Genoa, Italy

[3] Univ Campania Luigi Vanvitelli, Div Neurol 2, Naples, Italy

[4] St Andrea Hosp, Dept Neurol, Rome, Italy

[5] Univ Hosp Verona, Multiple Sclerosis Ctr, Dept Neurosci Biomed & Movement, Verona, Italy

[6] City Hlth & Sci Univ Hosp Turin, MS Ctr, Dept Neurosci, Turin, Italy

[7] Univ Genoa, Dept Neurol Rehabil Ophthalmol Genet Maternal & Ch, Genoa, Italy

[8] Montichiari Hosp, ASST Spedali Civili Brescia, Multiple Sclerosis Ctr, Brescia, Italy

[9] Bianchi Melacrino Morelli Great Metropolitan Hosp, MS Ctr, Reggio Di Calabria, Italy

[10] Osped Angelo, Neurol Unit, Venice, Italy

[11] IRCCS Neuromed, Dept Neurol, Pozzilli, Italy

[12] Univ Campania Luigi Vanvitelli, MS Ctr, Dept Adv Med & Surg Sci, Div Neurol 1, Naples, Italy

[13] Santa Lucia Fdn IRCCS, MS Ctr, Rome, Italy

[14] Hacettepe Univ, Fac Med, Ankara, Turkiye

[15] Tor Vergata Univ, MS Ctr, Rome, Italy

[16] Univ Cagliari, Binaghi Hosp, Multiple Sclerosis Ctr, ASL Cagliari, Cagliari, Italy

[17] IRCCS San Raffaele Hosp, Multiple Sclerosis Ctr, Neurol Dept, Milan, Italy

[18] Univ Palermo, BIND Dept, Palermo, Italy

[19] Inst Fdn G Giglio, MS Ctr, Cefalu, Italy

[20] Ondokuz Mayis Univ, Sch Med, Samsun, Turkiye

[21] S Paolo Hosp, MS Ctr, Naples, Italy

[22] Univ Hosp G Rodol, Multiple Sclerosis Unit, Catania, Italy

[23] Univ Catania, Dept Biomed & Biotechnol Sci, Catania, Italy

[24] Legnano Gen Hosp, ASST OVEST MI, Multiple Sclerosis Ctr, Legnano, Italy

[25] Cerrahpasa Univ, Fac Med, Istanbul, Turkiye

[26] IRCCS Osped Policlin San Martino, Genoa, Italy

[27] IRCCS Fdn Don Carlo Gnocchi, Florence, Italy

[28] Univ Genoa, Dept Hlth Sci, Sect Biostat, Via G Pastore 1, I-16132 Genoa, Italy

来源：

MULTIPLE SCLEROSIS JOURNAL | 2024年 / 30卷 / 06期

关键词：

Multiple sclerosis; pregnancy; COVID-19; SARS-CoV-2; infection; maternal outcomes; fetal outcomes; DIAGNOSTIC-CRITERIA; CORONAVIRUS; REVISIONS;

D O I：

10.1177/13524585241232266

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: In the general population, maternal COVID-19 is associated with worse maternal and fetal outcomes. Two previous studies have assessed COVID-19 clinical outcomes in pregnant women with multiple sclerosis (MS), but there are no data about maternal and fetal outcomes.Objectives: In this multicenter study, we aimed to assess maternal and fetal outcomes in pregnant women with MS and COVID-19 infection.Methods: We recruited pregnant patients with MS who contracted COVID-19 and were followed up in Italian and Turkish Centers, during 2020-2022. A control group was extracted from a previous Italian cohort. Associations between group (COVID-19 or healthy patients) and clinical outcomes (maternal complications, fetal malformations, and spontaneous abortion) were investigated with a weighted logistic regression where propensity score-based inverse probability of treatment weighting (IPTW) approach was applied for adjusting for difference in baseline confounders.Results: In the multivariable analysis, COVID-19 during pregnancy was associated with a higher risk of maternal complications (odd ratio (OR) = 2.12; 95% confidence interval (CI) = 1.32-3.48; p = 0.002), while it was not associated with higher risk of spontaneous abortion and fetal malformations.Conclusion: Our data indicate that COVID-19 during pregnancy increases the risk of maternal complications, while it seems to have no significant impact on fetal outcomes.

引用

页码：707 / 713

页数：7

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