Low thyroid function is associated with metabolic dysfunction-associated steatotic liver disease

被引:5
作者
Wang, Shuo [1 ]
Xia, Ding [1 ,4 ]
Fan, Hong [1 ]
Liu, Zhenqiu [2 ,5 ]
Chen, Ruilin [1 ]
Suo, Chen [1 ,3 ,5 ,6 ]
Zhang, Tiejun [1 ,3 ,5 ,7 ]
机构
[1] Fudan Univ, Sch Publ Hlth, Dept Epidemiol, Shanghai, Peoples R China
[2] Fudan Univ, State Key Lab Genet Engn, Sch Life Sci, Human Phenome Inst, Shanghai, Peoples R China
[3] Fudan Univ, Shanghai Inst Infect Dis & Biosecur, Sch Publ Hlth, Shanghai, Peoples R China
[4] Shanghai Jiao Tong Univ, Ruijin Hosp, Lifecycle Hlth Management Ctr, Sch Med, Shanghai, Peoples R China
[5] Fudan Univ, Taizhou Inst Hlth Sci, Taizhou, Peoples R China
[6] Fudan Univ, Sch Publ Hlth, Shanghai 200032, Peoples R China
[7] Fudan Univ, Sch Publ Hlth, Epidemiol, Shanghai 200032, Peoples R China
来源
JGH OPEN | 2024年 / 8卷 / 02期
关键词
low thyroid function; metabolic dysfunction-associated steatotic liver disease; thyroid stimulating hormone; HORMONES;
D O I
10.1002/jgh3.13038
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background and Aim: Metabolic dysfunction-associated steatotic liver disease (MASLD) is recently introduced to better highlight the pathogenic significance of cardiometabolic dysfunction, as compared with non-alcoholic fatty liver disease. This study aimed to investigate the association between low thyroid function and MASLD in the new context. Methods: We recruited 2901 participants for our retrospective cohort study from 2016 to 2021. Participants were divided into strict-normal thyroid function and low thyroid function groups (low-normal thyroid function, subclinical hypothyroidism) based on initial thyroid stimulating hormone (TSH) levels, respectively. Cox regression models were used to estimate the hazard ratios (HRs) and 95% CI. Results: During a median follow-up of 15.6 months, 165 (8.9%) strict-normal thyroid function subjects and 141 (13.4%) low thyroid function subjects developed MASLD; this result was statistically relevant (P < 0.05). Univariate regression analysis showed that low thyroid function and subclinical hypothyroidism were statistically significantly associated with MASLD (low thyroid function: HR1.53; 95% CI 1.22-1.92; subclinical hypothyroidism: HR1.95; 95% CI 1.47-2.60). Conclusions: MASLD is associated with low thyroid function and the relationship between MASLD and low thyroid function is independent.
引用
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页数:6
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