Lactoferrin Has a Protective Effect on Mouse Brain Cells after Acute Gamma Irradiation of the Head

被引：1
作者：
Kopaeva, M. Yu. [1 ]
Cherepov, A. B. [1 ,2 ]
Zaraiskaya, I. Yu. [3 ]
机构：
[1] Kurchatov Inst, Natl Res Ctr, Moscow, Russia
[2] Res Inst Gen Pathol & Pathophysiol, Moscow, Russia
[3] PK Anokhin Res Inst Normal Physiol, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2023年 / 176卷 / 02期
关键词：
human lactoferrin; acute gamma irradiation of the head; dentate gyrus of the hippocampus; cellular proliferation; TUNEL; DENTATE GYRUS; IONIZING-RADIATION; ADULT; EXPRESSION; APOPTOSIS; DAMAGE;
D O I：
10.1007/s10517-024-06004-3
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the effect of human lactoferrin on cells of the hippocampal dentate gyrus of 2-2.5-month-old male C57BL/6 mice after acute gamma irradiation of the head in a dose of 8 Gy from a 60Co source. Immediately after irradiation some animals received an intraperitoneal injection of human lactoferrin (4 mg/mouse). The appearance of TUNEL+ cells in the subgranular zone 6 h after irradiation was accompanied by a corresponding decrease in the number of Ki-67- and DCX-immunoreactive cells. Administration of lactoferrin had a protective effect on mouse brain cells, which manifested in a decrease in the number of TUNEL+ cells (by 77% relative to the irradiation alone) and an increase in the number of proliferating cells (from 16 to 61% relative to control animals) and immature neurons (from 14 to 22% relative to control animals) in the dentate gyrus of the hippocampus.
引用
收藏
页码：232 / 234
页数：3
相关论文
共 30 条
  • [1] Adult neurogenesis in the mammalian dentate gyrus
    Abbott, Louise C.
    Nigussie, Fikru
    [J]. ANATOMIA HISTOLOGIA EMBRYOLOGIA, 2020, 49 (01) : 3 - 16
  • [2] Cellular internalization of lactoferrin in intestinal epithelial cells
    Ashida, K
    Sasaki, H
    Suzuki, YA
    Lönnerdal, B
    [J]. BIOMETALS, 2004, 17 (03) : 311 - 315
  • [3] Molecular, Cellular and Functional Effects of Radiation-Induced Brain Injury: A Review
    Balentova, Sona
    Adamkov, Marian
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2015, 16 (11) : 27796 - 27815
  • [4] Lactoferrin Promotes Early Neurodevelopment and Cognition in Postnatal Piglets by Upregulating the BDNF Signaling Pathway and Polysialylation
    Chen, Yue
    Zheng, Zhiqiang
    Zhu, Xi
    Shi, Yujie
    Tian, Dandan
    Zhao, Fengjuan
    Liu, Ni
    Hueppi, Petra S.
    Troy, Frederic A., II
    Wang, Bing
    [J]. MOLECULAR NEUROBIOLOGY, 2015, 52 (01) : 256 - 269
  • [5] Franklin KBJ, 2007, Paxinos and Franklin's The mouse brain in stereotaxic coordinates
  • [6] Lactoferrin-modified nanoparticles could mediate efficient gene delivery to the brain in vivo
    Huang, Rongqin
    Ke, Weilun
    Han, Liang
    Liu, Yang
    Shao, Kun
    Jiang, Chen
    Pei, Yuanying
    [J]. BRAIN RESEARCH BULLETIN, 2010, 81 (06) : 600 - 604
  • [7] Role of LRP1 and ERK and cAMP Signaling Pathways in Lactoferrin-Induced Lipolysis in Mature Rat Adipocytes
    Ikoma-Seki, Keiko
    Nakamura, Kanae
    Morishita, Satoru
    Ono, Tomoji
    Sugiyama, Keikichi
    Nishino, Hoyoku
    Hirano, Hisashi
    Murakoshi, Michiaki
    [J]. PLOS ONE, 2015, 10 (10):
  • [8] The DNA-damage response in human biology and disease
    Jackson, Stephen P.
    Bartek, Jiri
    [J]. NATURE, 2009, 461 (7267) : 1071 - 1078
  • [9] Apo- and Holo-Lactoferrin Are Both Internalized by Lactoferrin Receptor via Clathrin-Mediated Endocytosis But Differentially Affect ERK-Signaling and Cell Proliferation in Caco-2 Cells
    Jiang, Rulan
    Lopez, Veronica
    Kelleher, Shannon L.
    Loennerdal, Bo
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2011, 226 (11) : 3022 - 3031
  • [10] The utility of Ki-67 and BrdU as proliferative markers of adult neurogenesis
    Kee, N
    Sivalingam, S
    Boonstra, R
    Wojtowicz, JM
    [J]. JOURNAL OF NEUROSCIENCE METHODS, 2002, 115 (01) : 97 - 105
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