Synthesis of 1,3,4-oxadiazoles with 4-methoxynaphthalene ring: discovering new compounds with antimicrobial activity

被引：3

作者：

Frederico Rozada, Andrew Matheus ^{[1
]}

Vilugron Rodrigues-Vendramini, Franciele Abigail ^{[2
]}

Kioshima, Erika Seki ^{[2
]}

Sampiron, Eloisa Gibin ^{[3
]}

de Lima Scodro, Regiane Bertin ^{[4
]}

Caleffi-Ferracioli, Katiany Rizzieri ^{[4
]}

Vicente Seixas, Flavio Augusto ^{[5
]}

Basso, Ernani Abicht ^{[1
]}

de Freitas Gauze, Gisele ^{[1
]}

机构：

[1] Univ Estadual Maringa, Chem Dept, BR-87020900 Maringa, PR, Brazil

[2] Univ Estadual Maringa, Dept Clin Anal & Biomed, Lab Med Mycol, BR-87020900 Maringa, PR, Brazil

[3] Univ Estadual Maringa, Postgrad Program Hlth Sci, BR-87020900 Maringa, PR, Brazil

[4] Univ Estadual Maringa, Dept Clin Anal & Biomed, BR-87020900 Maringa, PR, Brazil

[5] Univ Estadual Maringa, Dept Technol, BR-87506370 Umuarama, PR, Brazil

来源：

FUTURE MEDICINAL CHEMISTRY | 2023年 / 15卷 / 24期

关键词：

1-3-4-oxadiazoles; 4-methoxynaphthalene; co-infection; paracoccidioidomycosis; tuberculosis; ORAL PARACOCCIDIOIDOMYCOSIS; PULMONARY TUBERCULOSIS; EPIDEMIOLOGY; ALDEHYDES; EFFICIENT;

D O I：

10.4155/fmc-2023-0153

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Background: Paracoccidioidomycosis (PCM) is a systemic infection caused by Paracoccidioides spp. (Pb). PCM can be associated or clinically confused with tuberculosis (TB), another pulmonary infection, caused by Mycobacterium tuberculosis (Mtb). Futhermore, the long treatment time of TB and PCM and the cases of TB drug resistance impose difficulties for the cure of these diseases. Results: New 1,3,4-oxadiazoles containing the 4-methoxynaphthalene ring were synthesized and their antimicrobial activity was evaluated against Pb and Mtb. The derivative 6n (with 2-hydroxy-5-nitrophenyl subunit) is the most promising of the series. Conclusion: The 1,3,4-oxadiazole 6n can be used as a prototype drug candidate, with anti-Pb and anti-MTb activities, showing a broad-spectrum profile for the treatment of both pulmonary infections. [Graphical abstract]

引用

页码：2239 / 2255

页数：17

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