New Challenges and Prospective Applications of Three-Dimensional Bioactive Polymeric Hydrogels in Oral and Craniofacial Tissue Engineering: A Narrative Review

被引：21

作者：

Atia, Gamal Abdel Nasser ^{[1
]}

Shalaby, Hany K. K. ^{[2
]}

Ali, Naema Goda ^{[1
]}

Morsy, Shaimaa Mohammed ^{[1
]}

Ghobashy, Mohamed Mohamady ^{[3
]}

Attia, Hager Abdel Nasser ^{[4
]}

Barai, Paritosh ^{[5
]}

Nady, Norhan ^{[6
]}

Kodous, Ahmad S. S. ^{[7
]}

Barai, Hasi Rani ^{[8
]}

机构：

[1] Suez Canal Univ, Fac Dent, Dept Oral Med Periodontol & Diag, POB 41522, Ismailia, Egypt

[2] Suez Univ, Fac Dent, Dept Oral Med Periodontol & Oral Diag, POB 43512, Suez, Egypt

[3] Egyptian Atom Energy Author, Natl Ctr Radiat Res & Technol NCRRT, Radiat Res Polymer Chem Dept, POB 13759, Cairo, Egypt

[4] Alexandria Univ, Fac Sci, Dept Mol Biol & Chem, POB 21526, Alexandria, Egypt

[5] Primeasia Univ, Dept Biochem & Mol Biol, Dhaka 1213, Bangladesh

[6] City Sci Res & Technol Applicat SRTA City, Adv Technol & New Mat Res Inst ATNMRI, Polymer Mat Res Dept, POB 21934, Alexandria, Egypt

[7] Egyptian Atom Energy Author EAEA, Natl Ctr Radiat Res & Technol, Dept Radiat Biol, POB 13759, Cairo 13759, Egypt

[8] Yeungnam Univ, Dept Mech Engn, Gyongsan 38541, South Korea

来源：

PHARMACEUTICALS | 2023年 / 16卷 / 05期

关键词：

three dimensional; hydrogel scaffolds; tissue engineering; polymeric hydrogels and tissues regeneration; MESENCHYMAL STEM-CELLS; BONE REGENERATION; DRUG-DELIVERY; NANOCOMPOSITE HYDROGEL; PERIODONTAL REGENERATION; POLY(PROPYLENE FUMARATE); BIOMEDICAL APPLICATIONS; COMPOSITE SCAFFOLD; SUSTAINED-RELEASE; HYALURONIC-ACID;

D O I：

10.3390/ph16050702

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Regenerative medicine, and dentistry offers enormous potential for enhancing treatment results and has been fueled by bioengineering breakthroughs over the previous few decades. Bioengineered tissues and constructing functional structures capable of healing, maintaining, and regenerating damaged tissues and organs have had a broad influence on medicine and dentistry. Approaches for combining bioinspired materials, cells, and therapeutic chemicals are critical in stimulating tissue regeneration or as medicinal systems. Because of its capacity to maintain an unique 3D form, offer physical stability for the cells in produced tissues, and replicate the native tissues, hydrogels have been utilized as one of the most frequent tissue engineering scaffolds during the last twenty years. Hydrogels' high water content can provide an excellent conditions for cell viability as well as an architecture that mimics real tissues, bone, and cartilage. Hydrogels have been used to enable cell immobilization and growth factor application. This paper summarizes the features, structure, synthesis and production methods, uses, new challenges, and future prospects of bioactive polymeric hydrogels in dental and osseous tissue engineering of clinical, exploring, systematical and scientific applications.

引用

页数：37

共 246 条

[1] Biomimetic Nylon 6-Baghdadite Nanocomposite Scaffold for Bone Tissue Engineering [J].