Identification of Artemisia Argyi (AA) Therapy in Alzheimer's Disease (AD) Using Network Pharmacology and Molecular Docking

被引:1
|
作者
Wang, Yin [1 ]
Huang, Ruixue [1 ]
机构
[1] Cent South Univ, Xiangya Sch Publ Hlth, Dept Occupat & Environm Hlth, Changsha 410078, Hunan, Peoples R China
来源
ADVANCED BIOLOGY | 2023年 / 7卷 / 10期
基金
中国国家自然科学基金;
关键词
Alzheimer's disease; Artemisia argyi; docking activity; oral bioavailability;
D O I
10.1002/adbi.202200256
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
This study aims to investigate the molecular mechanism of Artemisia argyi (AA) in the treatment of cognitive impairment of Alzheimer's disease (AD) and the docking activity of AA on potential therapeutic targets using network pharmacology and molecular docking techniques. Bioinformatic analysis showed that neuroactive ligand-receptor interaction, the pathway of cancer, calcium signaling, neurodegeneration-multiple disease, and chemical carcinogenesis-receptor activation might be the related signal pathway in AA-AD. Moreover, the binding energy of AA active compounds to potential targets are <=-4.16 kJ mol(-1) with 10 patterns <=-10 kJ mol(-1). The results of molecular docking showed that there would be a stable binding ability between the active components of AA and potential target genes. Among them, 24-methylenecyloartanone, beta-sitosterol, and Stigmasterol are active components with potential oral bioavailability (OB), drug-likeness (DL), and blood-brain-barrier(BBB) are screened out with the stable binding ability to target genes, which may be potential components of AA treatment for AD. This study laid an important foundation for further study of the molecular mechanism of AA treatment for AD.
引用
收藏
页数:6
相关论文
共 50 条
  • [21] Network Pharmacology and Molecular Docking Identify the Potential Mechanism and Therapeutic Role of Scutellaria baicalensis in Alzheimer's Disease [Letter]
    Yulion, Rizky
    Andriani, Lili
    Aliyah, Siti Hamidatul
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2024, 18 : 1497 - 1498
  • [22] Study on the Mechanism of Acori Graminei Rhizoma in th Treatment of Alzheimer's Disease Based on Network Pharmacology and Molecular Docking
    Du, Yi Kuan
    Xiao, Yue
    Zhong, Shao Min
    Huang, Yi Xing
    Chen, Qian Wen
    Zhou, Yu Qi
    Guo, Jin Yan
    Yang, Chun
    BIOMED RESEARCH INTERNATIONAL, 2021, 2021
  • [23] Integration of Network Pharmacology and Molecular Docking Technology Reveals the Mechanism of the Therapeutic Effect of Xixin Decoction on Alzheimer's Disease
    Zhang, Zhuo
    Xu, Jianglin
    Ma, Suya
    Lin, Nan
    Hou, Minzhe
    Wei, Mingqing
    Li, Ting
    Shi, Jing
    COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 2022, 25 (10) : 1785 - 1804
  • [24] Pharmacology of Memory Dysfunction in Alzheimer's Disease (AD)
    Ratner, Marcia
    Farb, David H.
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2023, 385
  • [25] Molecular Mechanisms of Dietary Bioactive Peptides in Treating Alzheimer's Disease and Mild Cognitive Impairment by Network Pharmacology and Molecular Docking Analysis
    Li, Ruirui
    Zi, Jing
    Hu, Yifan
    Li, Xinlong
    Cao, Qianqian
    Li, Yanliu
    Wang, Xiaoyu
    Xiong, Jingyuan
    Cheng, Guo
    REJUVENATION RESEARCH, 2025,
  • [26] Network pharmacology and molecular docking-based systemic approach to investigate the mechanism and molecular targets of phloridzin against Alzheimer's disease
    Aiswarya, G. Nambiyar
    Brindha, Durairaj
    RESEARCH JOURNAL OF BIOTECHNOLOGY, 2024, 19 (06): : 127 - 136
  • [27] Molecular mechanisms of Huanglian Jiedu decoction in treating Alzheimer's disease by regulating microbiome via network pharmacology and molecular docking analysis
    Zheng, Renyuan
    Shi, Shenggan
    Zhang, Qin
    Yuan, Shuqin
    Guo, Tong
    Guo, Jinlin
    Jiang, Peidu
    FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2023, 13
  • [28] Investigating the Potential Anti-Alzheimer's Disease Mechanism of Marine Polyphenols: Insights from Network Pharmacology and Molecular Docking
    Youn, Kumju
    Ho, Chi-Tang
    Jun, Mira
    MARINE DRUGS, 2023, 21 (11)
  • [29] Network Pharmacology and Molecular Docking-Based Strategy to Investigate the Multitarget Mechanisms of Shenqi Yizhi Granule on Alzheimer's Disease
    Wang, Linshuang
    Xu, Xiaoyu
    Wang, Zikang
    Chen, Qian
    Wei, Xiaodie
    Xue, Jingfan
    Zhang, Zhanjun
    Wang, Miao
    Li, Yanping
    Zhang, Junying
    Wei, Dongfeng
    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2022, 2022
  • [30] Revealing the Mechanisms of Byu dMar 25 in the Treatment of Alzheimer's Disease through Network Pharmacology, Molecular Docking, and In Vivo Experiment
    Du, Yikuan
    Guo, Jinyan
    Zhou, Yuqi
    Yan, Simin
    Xu, Bijun
    Wang, Yuni
    Lu, Duoduo
    Ma, Zhendong
    Chen, Qianwen
    Tang, Qibin
    Zhang, Weichui
    Zhu, Jinfeng
    Huang, Yixing
    Yang, Chun
    ACS OMEGA, 2023, 8 (28): : 25066 - 25080