Base editing ablates all protein-coding genes of the mitochondrial genome in mouse cells

被引：0
|
作者：
Arimura, Shin-ichi [1 ]
机构：
[1] Univ Tokyo, Tokyo, Japan
来源：
NATURE BIOMEDICAL ENGINEERING | 2023年 / 7卷 / 05期
关键词：
D O I：
10.1038/s41551-022-00986-z
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The inability to precisely manipulate mammalian mitochondrial DNA has stalled our understanding of mitochondrial biology and the generation of cellular and animal models in which to study it. DNA base editing technologies have enabled the generation of a library of mitochondrial base editors that precisely ablate every protein-coding gene in the mouse mitochondrial genome.
引用
收藏
页码：614 / 615
页数：2
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