Hyperuricemia research progress in model construction and traditional Chinese medicine interventions

被引：18

作者：

Zhou, Hongyan ^{[1
,2
]}

Yang, Jingyi ^{[1
]}

Yuan, Xiaoqing ^{[1
]}

Song, Xinyu ^{[1
]}

Zhang, Xingcai ^{[3
]}

Cao, Ting ^{[4
]}

Zhang, Jiayu ^{[1
]}

机构：

[1] Binzhou Med Univ, Inst Chinese Med, Yantai, Shandong, Peoples R China

[2] Univ TCM, Sch Pharm, Jinan, Shandong, Peoples R China

[3] World Tea Org, Cambridge, MA 02138 USA

[4] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Hangzhou, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2024年 / 15卷

基金：

中国国家自然科学基金;

关键词：

hyperuricemia; traditional Chinese medicine; urate lowering; hyperuricemia models; efficacy evaluation; SERUM URIC-ACID; OXONATE-INDUCED HYPERURICEMIA; XANTHINE-OXIDASE; MECHANISM; MICE; TRANSPORTERS; INFLAMMATION; EXCRETION; FORMULA; RATS;

D O I：

10.3389/fphar.2024.1294755

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hyperuricemia (HUA), a severe metabolic disease derived from purine metabolism disorder, will lead to abnormally increased serum uric acid (SUA) levels in the body. Studies have shown that HUA is highly related to gout, hypertension, diabetes, coronary heart disease, chronic kidney diseases, and so on. Traditional Chinese medicine (TCM) shows excellent results in treating HUA because of its unique advantages of multi-metabolites and multi-targets. This article reports on the use of TCM components for uric acid (UA)-lowering activity with excellent efficacy and low side effects based on established HUA models. This work summarizes the advantages and limitations of various HUA disease models for efficacy evaluation. Applications of TCM in HUA treatment have also been discussed in detail. This paper reveals recent research progress on HUA in constructing evaluation models and systematic TCM interventions. It will provide a scientific reference for establishing the HUA model and suggest future TCM-related HUA studies.

引用

页数：16

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