The role of microbial metabolites in endocrine tumorigenesis: From the mechanistic insights to potential therapeutic biomarkers

被引：5

作者：

Zhang, Yiyi ^{[1
]}

Tang, Nie ^{[1
]}

Zhou, Hui ^{[1
]}

Zhu, Ying ^{[1
]}

机构：

[1] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sch Med, Dept Endocrinol, Chengdu 610072, Sichuan, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2024年 / 172卷

关键词：

Endocrine tumors; Microbial metabolites; HDAC; Immune response; Cellular signaling; Biomarker; CHAIN FATTY-ACIDS; HISTONE DEACETYLASE INHIBITORS; PANCREATIC-CANCER CELLS; TOLL-LIKE RECEPTORS; PROTEIN-KINASE-C; GUT MICROBIOTA; SODIUM-BUTYRATE; BILE-ACIDS; COLORECTAL-CANCER; OVARIAN-CANCER;

D O I：

10.1016/j.biopha.2024.116218

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Microbial metabolites have been indicated to communicate with the host's endocrine system, regulating hormone production, immune-endocrine communications, and interactions along the gut-brain axis, eventually affecting the occurrence of endocrine cancer. Furthermore, microbiota metabolites such as short-chain fatty acids (SCFAs) have been found to affect the tumor microenvironment and boost immunity against tumors. SCFAs, including butyrate and acetate, have been demonstrated to exert anti-proliferative and anti-protective activity on pancreatic cancer cells. The employing of microbial metabolic products in conjunction with radiation and chemotherapy has shown promising outcomes in terms of reducing treatment side effects and boosting effectiveness. Certain metabolites, such as valerate and butyrate, have been made known to improve the efficiency of CAR T-cell treatment, whilst others, such as indole-derived tryptophan metabolites, have been shown to inhibit tumor immunity. This review explores the intricate interplay between microbial metabolites and endocrine tumorigenesis, spanning mechanistic insights to the discovery of potential therapeutic biomarkers.

引用

页数：17

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