Molecular signaling network and therapeutic developments in breast cancer brain metastasis

被引：3

作者：

Benjamin, Mercilena ^{[1
]}

Malakar, Pushkar ^{[2
]}

Sinha, Rohit Anthony ^{[3
]}

Nasser, Mohd Wasim ^{[4
,5
]}

Batra, Surinder K. ^{[4
,5
]}

Siddiqui, Jawed Akhtar ^{[4
,5
]}

Chakravarti, Bandana ^{[3
]}

机构：

[1] All India Inst Med Sci, Lab Oncol Dr BRAIRCH, New Delhi, India

[2] Ramakrishna Mission Vivekananda Educ & Res Inst R, Sch Biol Sci, Dept Biomed Sci & Technol, Narendrapur 700103, W Bengal, India

[3] Sanjay Gandhi Postgrad Inst Med Sci, Dept Endocrinol, Lucknow 226014, India

[4] Univ Nebraska, Med Ctr, Dept Biochem & Mol Biol, Omaha, NE 68198 USA

[5] Univ Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Omaha, NE 68108 USA

来源：

ADVANCES IN CANCER BIOLOGY-METASTASIS | 2023年 / 7卷

基金：

英国惠康基金;

关键词：

Breast cancer; Brain metastasis; Blood-brain barrier; Signaling pathways; Targeted therapies; TO-MESENCHYMAL TRANSITION; NERVOUS-SYSTEM METASTASES; TUMOR BARRIER; DNA-REPAIR; CELLS; PROMOTES; PROGRESSION; EXPRESSION; SURVIVAL; GROWTH;

D O I：

10.1016/j.adcanc.2022.100079

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer (BC) is one of the most frequently diagnosed cancers in women worldwide. It has surpassed lung cancer as the leading cause of cancer-related death. Breast cancer brain metastasis (BCBM) is becoming a major clinical concern that is commonly associated with ER-ve and HER2+ve subtypes of BC patients. Metastatic lesions in the brain originate when the cancer cells detach from a primary breast tumor and establish metastatic lesions and infiltrate near and distant organs via systemic blood circulation by traversing the BBB. The colonization of BC cells in the brain involves a complex interplay in the tumor microenvironment (TME), metastatic cells, and brain cells like endothelial cells, microglia, and astrocytes. BCBM is a significant cause of morbidity and mortality and presents a challenge to developing successful cancer therapy. In this review, we discuss the molecular mechanism of BCBM and novel therapeutic strategies for patients with brain metastatic BC.

引用

页数：12

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