Roles of pyroptosis in atherosclerosis pathogenesis

被引：16

作者：

Liu, Xiaohan ^{[1
]}

Luo, Peiyi ^{[1
,2
]}

Zhang, Weiyun ^{[1
,2
]}

Zhang, Shuxian ^{[1
,2
]}

Yang, Shulong ^{[3
,4
,5
]}

Hong, Fenfang ^{[1
]}

机构：

[1] Nanchang Univ, Coll Med, Pathogen Biol Expt Ctr, Nanchang 330000, Jiangxi, Peoples R China

[2] Nanchang Univ, Jiangxi Med Coll, Queen Mary Sch, Nanchang 330000, Jiangxi, Peoples R China

[3] Nanchang Univ, Sch Basic Med Sci, Fuzhou Med Coll, Fuzhou 344000, Peoples R China

[4] Fuzhou Med Univ, Key Lab Chron Dis, Fuzhou 344000, Peoples R China

[5] Fuzhou Sci & Technol Bur, Technol Innovat Ctr Chron Dis Res Fuzhou City, Fuzhou 344000, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 166卷

基金：

中国国家自然科学基金;

关键词：

Cardiovascular diseases; Atherosclerosis; Inflammation; Pyroptosis; Macrophages; NLRP3 INFLAMMASOME ACTIVATION; CELL-DEATH RECOMMENDATIONS; GASDERMIN D; PATTERN-RECOGNITION; MACROPHAGE; RECEPTORS; GSDMD; CASPASE-11; INHIBITOR; DYSFUNCTION;

D O I：

10.1016/j.biopha.2023.115369

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Pyroptosis is a pro-inflammatory type of regulated cell death (RCD) characterized by gasdermin proteinmediated membrane pore formation, cell swelling, and rapid lysis. Recent studies have suggested that pyroptosis is closely related to atherosclerosis (AS). Previous studies reported that pyroptosis involving endothelial cells (ECs), macrophages, and smooth muscle cells (SMCs) plays an important role in the formation and development of AS. Pyroptosis not only causes local inflammation but also amplifies the inflammatory response and it aggravates plaque instability, leading to plaque rupture and thrombosis, eventually resulting in acute cardiovascular events. In this review, we clarified some novel pathways and mechanics and presented some potential drugs.

引用

页数：9

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