Rhodium(III)-Picolinamide Complexes Act as Anticancer and Antimetastasis Agents via Inducing Apoptosis and Autophagy

被引：22

作者：

Gu, Yun-Qiong ^{[1
,2
]}

Yang, Kun ^{[1
]}

Yang, Qi-Yuan ^{[1
]}

Li, Huan-Qing ^{[1
]}

Hu, Mei-Qi ^{[1
]}

Ma, Meng-Xue ^{[1
]}

Chen, Nan-Feng ^{[1
]}

Liu, Yang-Han ^{[1
]}

Liang, Hong ^{[1
]}

Chen, Zhen-Feng ^{[1
]}

机构：

[1] Guangxi Normal Univ, Collaborat Innovat Ctr Guangxi Ethn Med, Sch Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China

[2] Nanning Normal Univ, Sch Environm & Life Sci, Nanning 530001, Peoples R China

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2023年 / 66卷 / 14期

基金：

中国国家自然科学基金;

关键词：

RHODIUM METALLOINSERTORS; FLUORESCENT-PROBE; CANCER; INHIBITION; STRESS;

D O I：

10.1021/acs.jmedchem.3c00318

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

As a continuation of our endeavors in discovering metal-baseddrugswith cytotoxic and antimetastatic activities, herein, we reportedthe syntheses of 11 new rhodium(III)-picolinamide complexesand the exploration of their potential anticancer activities. TheseRh(III) complexes showed high antiproliferative activity against thetested cancer cell lines in vitro. The mechanism study indicated that Rh1 ([Rh(3a)(CH3CN)Cl-2])and Rh2 ([Rh(3b)(CH3CN)Cl-2]) inhibited cell proliferation by multiple modes of actionvia cell cycle arrest, apoptosis, and autophagy and inhibited cellmetastasis via FAK-regulated integrin & beta;1-mediated suppressionof EGFR expression. Furthermore, Rh1 and Rh2 significantly inhibited bladder cancer growth and breast cancermetastasis in a xenograft model. These rhodium(III) complexes couldbe developed as potential anticancer agents with antitumor growthand antimetastasis activity.

引用

页码：9592 / 9606

页数：15

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