Induced epigenetic changes memorized across generations in mice

被引：6

作者：

Cheng, Saifeng ^{[1
]}

Mayshar, Yoav ^{[1
]}

Stelzer, Yonatan ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Mol Cell Biol, IL-7610001 Rehovot, Israel

来源：

CELL | 2023年 / 186卷 / 04期

关键词：

INHERITANCE;

D O I：

10.1016/j.cell.2023.01.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transgenerational epigenetic inheritance in mammals has long been debatable. In this issue of Cell, Takaha-shi et al. induce DNA methylation at promoter-associated CpG islands (CGIs) of two metabolism-related genes and show that the acquired epigenetic changes and associated metabolic phenotypes are stably propagated across several generations in transgenic mice.

引用

页码：683 / 685

页数：3

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