The Influence of the microbiome on the innate immune microenvironment of solid tumors

被引:5
作者
Charles, Angel [1 ]
Thomas, Ryan M. [1 ,2 ,3 ]
机构
[1] Univ Florida, Dept Surg, Coll Med, Gainesville, FL USA
[2] Univ Florida, Dept Mol Genet & Microbiol, Coll Med, Gainesville, FL USA
[3] Univ Florida, Dept Surg, POB 100109, Gainesville, FL 32610 USA
来源
NEOPLASIA | 2023年 / 37卷
关键词
Innate immunity; Microbiome; Oncobiome; Cancer; Tumor microenvironment; NATURAL-KILLER-CELLS; DENDRITIC CELLS; MACROPHAGE POLARIZATION; FUSOBACTERIUM-NUCLEATUM; ANTITUMOR IMMUNITY; PROGNOSTIC-FACTOR; PERIPHERAL-BLOOD; GUT MICROBIOTA; STEADY-STATE; IFN-GAMMA;
D O I
10.1016/j.neo.2023.100878
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cancer remains a leading cause of death despite many advances in medical and surgical therapy. In recent decades, the investigation for novel therapeutic strategies with greater efficacy and reduced side effects has led to a deeper understanding of the relationship between the microbiome and the immune system in the context of cancer. The ability of the immune system to detect and kill cancer is now recognized to be greatly influenced by the microbial ecosystem of the host. While most of these studies, as well as currently used immunotherapeutics, focus on the adaptive immune system, this minimizes the impact of the innate immune system in cancer surveillance and its regulation by the host microbiome. In this review, known influences of the microbiome on the innate immune cells in the tumor microenvironment will be discussed in the context of individual innate immune cells. Current and needed areas of investigation will highlight the field and its potential impact in the clinical treatment of solid malignancies.
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页数:8
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