Risk of endometrial cancer after RRSO in BRCA 1/2 carriers: a multicentre cohort study

被引：0
|
作者：
Pla-Juher, Helena [1 ,2 ,4 ]
Pardo, Marta [2 ]
Izquierdo, Angel J. [2 ,3 ,4 ]
Darder, Esther [3 ,4 ]
Carbo, Anna [1 ,2 ,4 ]
Munte, Elisabet [5 ]
Torres-Esquius, Sara [6 ]
Balmana, Judith [6 ]
Lazaro, Concepcion [5 ,7 ]
Brunet, Joan M. [1 ,2 ,3 ,4 ]
Barretina-Ginesta, Maria-Pilar [1 ,2 ,4 ]
机构：
[1] Hosp Univ Dr Josep Trueta, Catalan Inst Oncol, Med Oncol, Avinguda Franca S-N, Girona 17707, Spain
[2] Inst Invest Biomed Girona IDIBGI, Precis Oncol Grp OncoGIR Pro, Girona, Spain
[3] IDIBGI, Catalan Inst Oncol, Hereditary Canc Program, Girona, Spain
[4] Dept Epidemiol & Canc Register, Girona, Spain
[5] IDIBELL, Catalan Inst Oncol, Hereditary Canc Program, Barcelona, Spain
[6] Vall dHebron Hosp, Dept Med Oncol, Barcelona, Spain
[7] Inst Salud Carlos III, Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain
来源：
CLINICAL & TRANSLATIONAL ONCOLOGY | 2024年 / 26卷 / 04期
关键词：
Endometrial cancer; Breast cancer; Risk-reducing salpingo-oophorectomy; BRCA; Mutation; Hysterectomy; Tamoxifen; Carcinosarcoma; Serous carcinoma; Endometrioid carcinoma; REDUCING SALPINGO-OOPHORECTOMY; UTERINE SEROUS CARCINOMA; BRCA2; MUTATIONS; BREAST-CANCER; WOMEN; HYSTERECTOMY; METAANALYSIS; SURGERY; TIME;
D O I：
10.1007/s12094-023-03312-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objective To know the risk of endometrial cancer (EC) in a population of women with BRCA 1/2 pathogenic or likely pathogenic variants after risk-reducing salpingo-oophorectomy (RRSO).Methods The study cohort included data from 857 women with BRCA mutations who underwent RRSO visited four hospitals in Catalonia, Spain, from January 1, 1999 to April 30, 2019. Standardized incidence ratio (SIR) of EC was calculated in these patients using data from a regional population-based cancer registry.Results After RRSO, eight cases of EC were identified. Four in BRCA 1 carriers and four in BRCA2 carriers. The expected number of cases of EC was 3.67 cases, with a SIR of 2.18 and a 95% CI (0.93-3.95).Conclusions In our cohort, the risk of EC in BRCA1/2 carriers after RRSO is not greater than expected. Hysterectomy is not routinely recommended for these patients.
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收藏
页码：1033 / 1037
页数：5
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