Mechanism of Qingchang Suppository on repairing the intestinal mucosal barrier in ulcerative colitis

被引：1

作者：

Shan, Jingyi ^{[1
,2
]}

Liu, Suxian ^{[1
,2
]}

Liu, Haoyue ^{[3
]}

Yuan, Jianye ^{[2
]}

Lin, Jiang ^{[1
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Gastroenterol, Shanghai, Peoples R China

[2] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Inst Digest Dis, Shanghai, Peoples R China

[3] Shanghai Univ Tradit Chinese Med, Intens Care Unit, Longhua Hosp, Shanghai, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2023年 / 14卷

基金：

中国国家自然科学基金;

关键词：

ulcerative colitis; Qingchang Suppository; active ingredients; intestinal mucosal barrier; mechanism; INFLAMMATORY-BOWEL-DISEASE; PANAX-NOTOGINSENG; INDIGO NATURALIS; OXIDATIVE STRESS; GUT MICROBIOTA; GALLIC ACID; PERMEABILITY; INHIBITION; ACTIVATION; MICE;

D O I：

10.3389/fphar.2023.1221849

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Ulcerative colitis (UC) is a refractory inflammatory bowel disease, and the outcomes of conventional therapies of UC, including 5-aminosalicylic acid, glucocorticoids, immunosuppressants, and biological agents, are not satisfied with patients and physicians with regard to adverse reactions and financial burden. The abnormality of the intestinal mucosal barrier in the pathogenesis of UC was verified. Qingchang Suppository (QCS) is an herbal preparation and is effective in treating ulcerative proctitis. The mechanism of QCS and its active ingredients have not been concluded especially in mucosal healing. This review elucidated the potential mechanism of QCS from the intestinal mucosal barrier perspective to help exploring future QCS research directions.

引用

页数：7

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