Biophysical interplay between extracellular matrix remodeling and hypoxia signaling in regulating cancer metastasis

被引：9

作者：

Lee, Sun-Ah ^{[1
]}

Cho, Gi-Ju ^{[1
]}

Kim, Doyoung ^{[1
]}

Kim, Dong-Hwee ^{[1
,2
,3
]}

机构：

[1] Korea Univ, KU KIST Grad Sch Converging Sci & Technol, Seoul, South Korea

[2] Korea Univ, Coll Engn, Dept Integrat Energy Engn, Seoul, South Korea

[3] Korea Inst Sci & Technol, Biomed Res Ctr, Seoul, South Korea

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2024年 / 12卷

基金：

新加坡国家研究基金会;

关键词：

tumor-microenvironment; ECM remodeling; hypoxia; cancer metastasis; mechano-signaling; mechano-regulation; cancer biophysics; PANCREATIC STELLATE CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; BREAST-CANCER; INDUCIBLE FACTOR-1-ALPHA; TUMOR MICROENVIRONMENT; MASTER REGULATOR; DOWN-REGULATION; STEM-CELLS; PORE-SIZE; EXPRESSION;

D O I：

10.3389/fcell.2024.1335636

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mechanical properties of the tumor microenvironment play a critical role in cancer progression by activation of cancer mechano-responses. The biophysical interactions between cancer cells and their dynamic microenvironment are attributed to force-dependent alterations in molecular pathways that trigger the structural reorganization of intracellular organelles and their associated genetic modifications. Recent studies underscore the role of oxygen concentration in cancer metastasis. Suppressed oxygen levels promote the development of invasive phenotypes and aggressive proliferation of cancer cells, accompanied by remodeling of tumor microenvironment encompassing the modulation of physical settings of extracellular matrix. This review summarizes the role of biophysical interactions between cancer cells and their surroundings in determining cancer progression. Biophysical interpretation of the tumor microenvironment and cancer progression could provide further insights into the development of novel biomedical technologies for therapeutic cancer treatment.

引用

页数：21

共 227 条

[1] Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration [J].

Acerbi, I. ;

Cassereau, L. ;

Dean, I. ;

Shi, Q. ;

Au, A. ;

Park, C. ;

Chen, Y. Y. ;

Liphardt, J. ;

Hwang, E. S. ;

Weaver, V. M. .

INTEGRATIVE BIOLOGY, 2015, 7 (10) :1120-1134

[2]

Akakura N, 2001, CANCER RES, V61, P6548

[3] C subunit of the ATP synthase is an amyloidogenic calcium dependent channel-forming peptide with possible implications in mitochondrial permeability transition [J].

Amodeo, Giuseppe Federico ;

Lee, Brenda Yasie ;

Krilyuk, Natalya ;

Filice, Carina Teresa ;

Valyuk, Denis ;

Otzen, Daniel Erik ;

Noskov, Sergey ;

Leonenko, Zoya ;

Pavlov, Evgeny V. .

SCIENTIFIC REPORTS, 2021, 11 (01)

[4] Dense fibrillar collagen is a potent inducer of invadopodia via a specific signaling network [J].

Artym, Vira V. ;

Swatkoski, Stephen ;

Matsumoto, Kazue ;

Campbell, Catherine B. ;

Petrie, Ryan J. ;

Dimitriadis, Emilios K. ;

Li, Xin ;

Mueller, Susette C. ;

Bugge, Thomas H. ;

Gucek, Marian ;

Yamada, Kenneth M. .

JOURNAL OF CELL BIOLOGY, 2015, 208 (03) :331-350

[5] Understanding the role of potential pathways and its components including hypoxia and immune system in case of oral cancer [J].

Bajrai, Leena Hussein ;

Sohrab, Sayed Sartaj ;

Mobashir, Mohammad ;

Kamal, Mohammad Amjad ;

Rizvi, Moshahid Alam ;

Azhar, Esam Ibraheem .

SCIENTIFIC REPORTS, 2021, 11 (01)

[6] Specific expression of matrix metalloproteinases 1, 3, 9 and 13 associated with invasiveness of breast cancer cells in vitro [J].

Balduyck, M ;

Zerimech, F ;

Gouyer, V ;

Lemaire, R ;

Hemon, B ;

Grard, G ;

Thiebaut, C ;

Lemaire, V ;

Dacquembronne, E ;

Duhem, T ;

Lebrun, A ;

Dejonghe, MJ ;

Huet, G .

CLINICAL & EXPERIMENTAL METASTASIS, 2000, 18 (02) :171-178

[7] The rationale for targeting the LOX family in cancer [J].

Barker, Holly E. ;

Cox, Thomas R. ;

Erler, Janine T. .

NATURE REVIEWS CANCER, 2012, 12 (08) :540-552

[8] Cell shape, and not 2D migration, predicts extracellular matrix-driven 3D cell invasion in breast cancer [J].

Baskaran, Janani P. ;

Weldy, Anna ;

Guarin, Justinne ;

Munoz, Gabrielle ;

Shpilker, Polina H. ;

Kotlik, Michael ;

Subbiah, Nandita ;

Wishart, Andrew ;

Peng, Yifan ;

Miller, Miles A. ;

Cowen, Lenore ;

Oudin, Madeleine J. .

APL BIOENGINEERING, 2020, 4 (02)

[9] MAP kinases and hypoxia in the control of VEGF expression [J].

Berra, E ;

Pagès, G ;

Pouysségur, J .

CANCER AND METASTASIS REVIEWS, 2000, 19 (1-2) :139-145

[10] Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy [J].

Bertero, Thomas ;

Oldham, William M. ;

Grasset, Eloise M. ;

Bourget, Isabelle ;

Boulter, Etienne ;

Pisano, Sabrina ;

Hofman, Paul ;

Bellvert, Floriant ;

Meneguzzi, Guerrino ;

Bulavin, Dmitry, V ;

Estrach, Soline ;

Feral, Chloe C. ;

Chan, Stephen Y. ;

Bozec, Alexandre ;

Gaggioli, Cedric .

CELL METABOLISM, 2019, 29 (01) :124-+

← 1 2 3 4 5 6 7 8 9 10 →