Coronavirus disease 2019 is associated with long-term depressive symptoms in Spanish older adults with overweight/obesity and metabolic syndrome

被引：4

作者：

Shyam, Sangeetha ^{[1
,2
,3
]}

Gomez-Martinez, Carlos ^{[1
,2
,3
]}

Paz-Graniel, Indira ^{[1
,2
,3
]}

Gaforio, Jose J. ^{[4
,5
]}

Martinez-Gonzalez, Miguel Angel ^{[1
,6
,7
]}

Corella, Dolores ^{[1
,8
]}

Fito, Montserrat ^{[1
,9
]}

Martinez, J. Alfredo ^{[1
,10
,11
]}

Alonso-Gomez, Angel M. ^{[1
,12
,13
,14
]}

Warnberg, Julia ^{[1
,15
]}

Vioque, Jesus ^{[4
,16
]}

Romaguera, Dora ^{[1
,17
]}

Lopez-Miranda, Jose ^{[1
,18
]}

Estruch, Ramon ^{[1
,19
,20
]}

Tinahones, Francisco J. ^{[1
,21
]}

Santos-Lozano, Jose Manuel ^{[1
,22
]}

Serra-Majem, J. Luis ^{[1
,23
,24
]}

Bueno-Cavanillas, Aurora ^{[4
,25
]}

Tur, Josep A. ^{[1
,26
]}

Sanchez, Vicente Martin ^{[4
,11
,27
]}

Pinto, Xavier ^{[1
,28
]}

Ramos, Maria ^{[29
]}

Vidal, Josep ^{[30
,31
]}

Alcarria, Maria Mar ^{[32
]}

Daimiel, Lidia ^{[1
,33
,35
]}

Ros, Emilio ^{[1
,34
]}

Fernandez-Aranda, Fernando ^{[1
,36
,37
,38
]}

Nishi, Stephanie K. ^{[1
,2
,3
,39
]}

Regata, Oscar Garcia ^{[40
]}

Toledo, Estefania ^{[1
,6
]}

Sorli, Jose V. ^{[1
,8
]}

Castaner, Olga ^{[9
]}

Garcia-Rios, Antonio ^{[1
,18
]}

Valls-Enguix, Rafael ^{[41
]}

Perez-Farinos, Napoleon ^{[1
,15
]}

Zulet, M. Angeles ^{[1
,10
]}

Rayo-Gago, Elena ^{[17
]}

Casas, Rosa ^{[1
,19
,20
]}

Rivera-Izquierdo, Mario ^{[25
]}

Tojal-Sierra, Lucas ^{[1
,12
,13
,14
]}

Damas-Fuentes, Miguel ^{[21
]}

Buil-Cosiales, Pilar ^{[1
,6
,42
]}

Fernandez-Carrion, Rebeca ^{[1
,8
]}

Goday, Albert ^{[9
]}

Pena-Orihuela, Patricia J. ^{[1
,18
]}

Compan-Gabucio, Laura ^{[4
,16
]}

Diez-Espino, Javier ^{[1
,6
,42
]}

Tello, Susanna ^{[9
]}

Gonzalez-Pinto, Ana ^{[43
,44
]}

de la O, Victor ^{[1
]}

机构：

[1] Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr C, Madrid, Spain

[2] Univ Rovirai I Virgili, Dept Bioquim & Biotecnol, Grp Alimentacio Nutr Desenvolupament & Salut Menta, Unitat Nutr Humana, Reus, Spain

[3] Inst Invest Sanitaria Pere Virgili IISPV, Reus, Spain

[4] Inst Salud Carlos III ISCIII, CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain

[5] Univ Jaen, Inst Univ Invest Olivar & Aceites Oliva, Dept Ciencias Salud, Jaen, Spain

[6] Univ Navarra, Dept Prevent Med & Publ Hlth, Inst Invest Sanitaria Navarra IdiSNA, Pamplona, Spain

[7] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA

[8] Univ Valencia, Dept Prevent Med, Valencia, Spain

[9] Inst Hosp del Mar Invest Med Municipal Invest Med, Unit Cardiovasc Risk & Nutr, Barcelona, Spain

[10] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona, Spain

[11] CEI UAM CSIC, Precis Nutr & Cardiometab Hlth Program, IEA Food, Madrid, Spain

[12] Araba Univ Hosp, Univ Basque Country UPV, Vitoria, Spain

[13] Araba Univ Hosp, Osakidetza Basque Hlth Serv, Vitoria, Spain

[14] Univ Basque Country UPV EHU, Vitoria, Spain

[15] Univ Malaga, Sch Hlth Sci, Inst Invest Biomed Malaga IBIMA, EpiPHAAN Res Grp, Malaga, Spain

[16] Univ Miguel Hernandez ISABIAL UMH, Inst Invest Sanitaria & Biomed Alicante, Alicante, Spain

[17] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca, Spain

[18] Univ Cordoba, Reina Sofia Univ Hosp, Dept Internal Med, Maimonides Biomed Res Inst Cordoba IMIBIC, Cordoba, Spain

[19] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Internal Med, Barcelona, Spain

[20] Univ Barcelona, Inst Recerca Nutr & Seguretat Alimentaria INSA UB, Barcelona, Spain

[21] Univ Malaga, Virgen de la Victoria Hosp, Dept Endocrinol, Inst Invest Biomed Malaga IBIMA, Malaga, Spain

[22] Dist Sanitario Atenc Primaria Sevilla, Dept Familiy Med, Res Unit, Seville, Spain

[23] Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci IUIBS, Las Palmas Gran Canaria, Spain

[24] Ctr Hosp Univ Insular Materno Infantil CHUIMI, Canarian Hlth Serv, Las Palmas Gran Canaria, Spain

[25] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain

[26] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain

[27] Univ Leon, Inst Biomed IBIOMED, Leon, Spain

[28] Hosp Univ Bellvitge IDIBELL, Internal Med, Lipids & Vasc Risk Unit, Hospitalet De Llobregat B, Barcelona, Spain

[29] Inst Invest Sanitaria Hosp Clin San Carlos IdISSC, Dept Endocrinol & Nutr, Madrid, Spain

[30] Inst Salud Carlos III ISCIII, CIBER Diabet & Enfermedades Metab CIBERDEM, Madrid, Spain

[31] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol, Barcelona, Spain

[32] Univ Autonoma, Hosp Fdn Jimenez Diaz, Dept Endocrinol & Nutr, Inst Invest Biomed IISFJD, Madrid, Spain

[33] CEI UAM CSIC, IMDEA Food, Precis Nutr & Obes Program, Nutr Contro,Epigenome Grp, Madrid, Spain

[34] Hosp Clin Barcelona, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol & Nutr, Lipid Clin, Barcelona, Spain

[35] Univ San Pablo CEU, CEU Univ, Fac Farm, Dept Ciencias Farmaceut & Salud, Boadilla Del Monte, Spain

[36] Inst Invest Biomed Bellvitge IDIBELL, Psychoneurobiol Eating & Addict Behav Grp, Barcelona, Spain

[37] Univ Hosp Bellvitge, Dept Psychiat, Barcelona, Spain

[38] Univ Barcelona, Barcelona, Spain

[39] Toronto 3D Diet Digest Tract & Dis, Knowledge Synth & Clin Trials Unit, Toronto, ON, Canada

[40] Univ Hosp Araba, Dept Internal Med, OSI ARABA, Vitoria, Spain

[41] Hlth Care Ctr Raval Elche, Elche, Spain

[42] Serv Navarro Salud, Atenc Primaria, Pamplona, Spain

[43] Araba Univ Hosp, Bioaraba Hlth Res Inst, Dept Psychiat, Osakidetza Basque Hlth Serv, Vitoria, Spain

[44] Univ Basque Country UPV EHU, CIBERSAM, Vitoria, Spain

[45] Univ Jaen, Fac Med, Div Prevent Med, Jaen, Spain

来源：

PSYCHOLOGICAL MEDICINE | 2024年 / 54卷 / 03期

基金：

欧盟地平线“2020”; 欧洲研究理事会; 加拿大健康研究院;

关键词：

COVID-19; depression; older adults; PREDIMED-Plus; SARS-CoV-2;

D O I：

10.1017/S0033291723002313

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Background. The coronavirus disease 2019 (COVID-19) has serious physiological and psychological consequences. The long-term (>12 weeks post-infection) impact of COVID19 on mental health, specifically in older adults, is unclear. We longitudinally assessed the association of COVID-19 with depression symptomatology in community-dwelling older adults with metabolic syndrome within the framework of the PREDIMED-Plus cohort. Methods. Participants (n = 5486) aged 55-75 years were included in this longitudinal cohort. COVID-19 status ( positive/negative) determined by tests (e.g. polymerase chain reaction severe acute respiratory syndrome coronavirus 2, IgG) was confirmed via event adjudication (410 cases). Pre- and post-COVID-19 depressive symptomatology was ascertained from annual assessments conducted using a validated 21-item Spanish Beck Depression Inventory-II (BDI-II). Multivariable linear and logistic regression models assessed the association between COVID-19 and depression symptomatology. Results. COVID-19 in older adults was associated with higher post-COVID-19 BDI-II scores measured at a median (interquartile range) of 29 (15-40) weeks post-infection [fully adjusted ss = 0.65 points, 95% confidence interval (CI) 0.15-1.15; p = 0.011]. This association was particularly prominent in women (ss = 1.38 points, 95% CI 0.44-2.33, p = 0.004). COVID-19 was associated with 62% increased odds of elevated depression risk (BDI-II >= 14) post-COVID-19 when adjusted for confounders (odds ratio; 95% CI 1.13-2.30, p = 0.008). Conclusions. COVID-19 was associated with long-term depression risk in older adults with overweight/obesity and metabolic syndrome, particularly in women. Thus, long-term evaluations of the impact of COVID-19 on mental health and preventive public health initiatives are warranted in older adults.

引用

页码：620 / 630

页数：11

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