Raman spectroscopy for viral diagnostics

被引:26
作者
Lukose, Jijo [1 ]
Barik, Ajaya Kumar [1 ]
Mithun, N. [1 ]
Pavithran, M. Sanoop [1 ]
George, Sajan D. [2 ]
Murukeshan, V. M. [3 ]
Chidangil, Santhosh [1 ]
机构
[1] Manipal Acad Higher Educ, Ctr Excellence Biophoton, Dept Atom & Mol Phys, Manipal 576104, India
[2] Manipal Acad Higher Educ, Ctr Appl Nanosci, Dept Atom & Mol Phys, Manipal 576104, India
[3] Nanyang Technol Univ, Ctr Opt & Laser Engn, Sch Mech & Aerosp Engn, 50 Nanyang Ave, Singapore 639798, Singapore
关键词
Virus; Raman spectroscopy; Surface-enhanced Raman spectroscopy; Tip-enhanced Raman spectroscopy; Raman tweezer; SARS-CoV-2; Point of care applications; SENSITIVE DETECTION; INFLUENZA-VIRUSES; NANOROD ARRAY; SERS; IDENTIFICATION; DNA; IMMUNOASSAY; SARS-COV-2; CELLS; CLASSIFICATION;
D O I
10.1007/s12551-023-01059-4
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Raman spectroscopy offers the potential for fingerprinting biological molecules at ultra-low concentration and therefore has potential for the detection of viruses. Here we review various Raman techniques employed for the investigation of viruses. Different Raman techniques are discussed including conventional Raman spectroscopy, surface-enhanced Raman spectroscopy, Raman tweezer, tip-enhanced Raman Spectroscopy, and coherent anti-Stokes Raman scattering. Surface-enhanced Raman scattering can play an essential role in viral detection by multiplexing nanotechnology, microfluidics, and machine learning for ensuring spectral reproducibility and efficient workflow in sample processing and detection. The application of these techniques to diagnose the SARS-CoV-2 virus is also reviewed.
引用
收藏
页码:199 / 221
页数:23
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