PAD2: A potential target for tumor therapy

被引：12

作者：

Teng, Yi ^{[1
,2
]}

Chen, Yuhang ^{[2
]}

Tang, Xinyi ^{[3
]}

Wang, Shengjun ^{[2
,3
]}

Yin, Kai ^{[1
]}

机构：

[1] Jiangsu Univ, Affiliated Hosp, Dept Gen Surg, Jiefang Rd 438, Zhenjiang 212002, Peoples R China

[2] Jiangsu Univ, Sch Med, Dept Immunol, Jiangsu Key Lab Lab Med, Zhenjiang, Peoples R China

[3] Jiangsu Univ, Affiliated Peoples Hosp, Dept Lab Med, Zhenjiang 212002, Peoples R China

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2023年 / 1878卷 / 05期

关键词：

Peptide arginine deiminase 2; Citrullination; Tumor; therapy; PEPTIDYLARGININE DEIMINASE 2; EXTRACELLULAR TRAP FORMATION; CITRULLINATED PROTEINS; STEM-CELLS; ACTIVATION; MACROPHAGES; EXPRESSION; GENE; INACTIVATORS; METHYLATION;

D O I：

10.1016/j.bbcan.2023.188931

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peptide arginine deiminase 2(PAD2) catalyzes the conversion of arginine residues on target proteins to citrulline residues in the presence of calcium ions. This particular posttranslational modification is called citrullination. PAD2 can regulate the transcriptional activity of genes through histone citrullination and nonhistone citrullination. In this review, we summarize the evidence from recent decades and systematically illustrate the role of PAD2-mediated citrullination in tumor pathology and the regulation of tumor-associated immune cells such as neutrophils, monocytes, macrophages and T cells. Several PAD2-specific inhibitors are also presented to discuss the feasibility of anti-PAD2 therapy to treat tumors and the urgent problems to be solved. Finally, we review some recent developments in the development of PAD2 inhibitors.

引用

页数：9

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