Palladium-Catalyzed Dearomatization of Indoles with Alkynes: Construction of Spirocyclohexaneindolenines

被引：0

作者：

Hu, Weiming ^{[1
]}

Huang, Jiali ^{[1
]}

Gao, Gang ^{[2
]}

Guo, Wenting ^{[1
]}

Yin, Fujun ^{[3
]}

Sun, Yang ^{[1
]}

Huang, Jingjiao ^{[1
]}

Tao, Chuanzhou ^{[1
]}

Tao, Li ^{[4
]}

Hu, Huayou ^{[5
]}

机构：

[1] Jiangsu Ocean Univ, Sch Environm & Chem Engn, Jiangsu Key Lab Funct Control Technol Adv Mat, Lianyungang 222005, Jiangsu, Peoples R China

[2] Jiangsu Prov Lianyungang Flood Control & Motorized, Lianyungang 222000, Jiangsu, Peoples R China

[3] Jiangsu Ocean Univ, Jiangsu Inst Marine Resources Dev, Lianyungang 222005, Jiangsu, Peoples R China

[4] Jiangsu Ocean Univ, Off Acad Affairs, Lianyungang 222005, Jiangsu, Peoples R China

[5] Huaiyin Normal Univ, Sch Chem & Chem Engn, Jiangsu Key Lab Chem Low Dimens Mat, Huaian 223300, Jiangsu, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 15期

关键词：

ENANTIOSELECTIVE CONSTRUCTION; ALLYLIC DEAROMATIZATION; CASCADE REACTIONS; SILVER(I); ACCESS; YNONES; ACID;

D O I：

10.1021/acs.joc.3c01041

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium-catalyzed dearomatization of indoles withalkynes hasbeen developed, providing an efficient route to access a variety ofsynthetically useful spirocyclohexaneindolenines in moderate to goodyields. The current method features a simple catalytic system, operationalsimplicity, and good functional group compatibility, which will contributesubstantially to the development of dearomatization to access spirocompounds. Besides, the ubiquitous existence of spiro molecules, includingspirocyclohexaneindolenines, in drugs and biological active moleculessuggests the potential application of this methodology in medicinalchemistry.

引用

页码：11335 / 11345

页数：11

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