The role of VEGF in cancer-induced angiogenesis and research progress of drugs targeting VEGF

被引:115
作者
Ghalehbandi, Seyedehdelaram [1 ]
Yuzugulen, Jale [1 ]
Pranjol, Md Zahidul Islam [2 ]
Pourgholami, Mohammad Hossein [3 ]
机构
[1] Eastern Mediterranean Univ, Fac Pharm, Via Mersin 10, Famagusta, North Cyprus, Turkiye
[2] Univ Sussex, Sch Life Sci, Brighton, England
[3] Tarbiat Modares Univ, Fac Med Sci, Dept Physiol, Tehran, Iran
关键词
Angiogenesis; Anti-angiogenic agents; Vascular endothelial growth factor; Anti-VEGF; Human solid cancers; ENDOTHELIAL GROWTH-FACTOR; RENAL-CELL CARCINOMA; METASTATIC COLORECTAL-CANCER; DIFFERENTIATED THYROID-CANCER; BEVACIZUMAB PLUS INTERFERON; PHASE-II TRIAL; DOUBLE-BLIND; OPEN-LABEL; 1ST-LINE TREATMENT; OVARIAN-CANCER;
D O I
10.1016/j.ejphar.2023.175586
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Angiogenesis is a double-edged sword; it is a mechanism that defines the boundary between health and disease. In spite of its central role in physiological homeostasis, it provides the oxygen and nutrition needed by tumor cells to proceed from dormancy if pro-angiogenic factors tip the balance in favor of tumor angiogenesis. Among pro-angiogenic factors, vascular endothelial growth factor (VEGF) is a prominent target in therapeutic methods due to its strategic involvement in the formation of anomalous tumor vasculature. In addition, VEGF exhibits immune-regulatory properties which suppress immune cell antitumor activity. VEGF signaling through its re-ceptors is an integral part of tumoral angiogenic approaches. A wide variety of medicines have been designed to target the ligands and receptors of this pro-angiogenic superfamily. Herein, we summarize the direct and indirect molecular mechanisms of VEGF to demonstrate its versatile role in the context of cancer angiogenesis and current transformative VEGF-targeted strategies interfering with tumor growth.
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页数:21
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共 269 条
[11]   Tumoral and stromal expression of MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2, and VEGF-A in cervical cancer patient survival: a competing risk analysis [J].
Azevedo Martins, Jordana Maria ;
Rabelo-Santos, Silvia Helena ;
do Amaral Westin, Maria Cristina ;
Zeferino, Luiz Carlos .
BMC CANCER, 2020, 20 (01)
[12]   Vascular endothelial growth factor suppresses dendritic cells function of human prostate cancer [J].
Bai, Wen-kun ;
Zhang, Wei ;
Hu, Bing .
ONCOTARGETS AND THERAPY, 2018, 11 :1267-1274
[13]   Vascular endothelial growth factor and bevacitumab in breast cancer. [J].
Bando H. .
Breast Cancer, 2007, 14 (2) :163-173
[14]   Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer [J].
Barr, Martin P. ;
Gray, Steven G. ;
Gately, Kathy ;
Hams, Emily ;
Fallon, Padraic G. ;
Davies, Anthony Mitchell ;
Richard, Derek J. ;
Pidgeon, Graham P. ;
O'Byrne, Kenneth J. .
MOLECULAR CANCER, 2015, 14
[15]  
Belotti D, 2003, CANCER RES, V63, P5224
[16]   Alternative Vascularization Mechanisms in Tumor Resistance to Therapy [J].
Belotti, Dorina ;
Pinessi, Denise ;
Taraboletti, Giulia .
CANCERS, 2021, 13 (08)
[17]   Efficacy and safety of motesanib, an oral inhibitor of VEGF, PDGF, and Kit receptors, in patients with imatinib-resistant gastrointestinal stromal tumors [J].
Benjamin, Robert S. ;
Schoffski, Patrick ;
Hartmann, Joerg Thomas ;
Van Oosterom, Allan ;
Binh Nguyen Bui ;
Duyster, Justus ;
Schuetze, Scott ;
Blay, Jean-Yves ;
Reichardt, Peter ;
Rosen, Lee S. ;
Skubitz, Keith ;
McCoy, Sheryl ;
Sun, Yu-Nien ;
Stepan, Daniel E. ;
Baker, Laurence .
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2011, 68 (01) :69-77
[18]   FDA Approval Summary: Sunitinib for the Treatment of Progressive Well-Differentiated Locally Advanced or Metastatic Pancreatic Neuroendocrine Tumors [J].
Blumenthal, Gideon M. ;
Cortazar, Patricia ;
Zhang, Jenny J. ;
Tang, Shenghui ;
Sridhara, Rajeshwari ;
Murgo, Anthony ;
Justice, Robert ;
Pazdur, Richard .
ONCOLOGIST, 2012, 17 (08) :1108-1113
[19]   SOCRATE-PRODIGE 55 trial: A randomized phase II study to evaluate second-line ramucirumab alone or with paclitaxel in older patients with advanced gastric cancer [J].
Boisteau, Emeric ;
Francois, Eric ;
Aparicio, Thomas ;
Le Malicot, Karine ;
Boulahssass, Rabia ;
Lecomte, Thierry ;
Laurent-Puig, Pierre ;
Guiu, Boris ;
Paillaud, Elena ;
Galais, Marie-Pierre ;
Ataz, Daniel Lopez-Trabada ;
Tougeron, David ;
Dourthe, Louis-Marie ;
Guimbaud, Rosine ;
Samalin, Emmanuelle ;
Moreau, Marie ;
Louvet, Christophe ;
Lepage, Come ;
Lievre, Astrid .
DIGESTIVE AND LIVER DISEASE, 2022, 54 (06) :747-754
[20]   Direct and Indirect Modulation of T Cells by VEGF-A Counteracted by Anti-Angiogenic Treatment [J].
Bourhis, Morgane ;
Palle, Juliette ;
Galy-Fauroux, Isabelle ;
Terme, Magali .
FRONTIERS IN IMMUNOLOGY, 2021, 12