Progress in the Total Synthesis of Antitumor Tetrahydroisoquinoline Alkaloids

被引：13

作者：

Gao, Yi ^{[1
]}

Tu, Ni ^{[1
]}

Liu, Xiaoting ^{[1
]}

Lu, Kangkang ^{[1
]}

Chen, Siyu ^{[1
]}

Guo, Ju ^{[1
]}

机构：

[1] Wuhan Inst Technol, Minist Educ, Dept Key Lab Green Chem Proc, Wuhan 430205, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2023年 / 20卷 / 05期

关键词：

tetrahydroisoquinoline alkaloid; natural product; antitumor activity; total synthesis; research progress; AB-RING-SYSTEM; ENANTIOSELECTIVE SYNTHESIS; ECTEINASCIDIN ET-743; (-)-JORUMYCIN; CYTOTOXICITY; SAFRAMYCIN; KW2152; FERMENTATION; TETRAZOMINE; DERIVATIVES;

D O I：

10.1002/cbdv.202300172

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Among the tetrahydroisoquinoline(THIQ) of natural products, a family of THIQ alkaloids has the characteristics of similar biosynthetic pathway. Such THIQ alkaloids family mainly include Renieramycins, Ecteinasicdins, Tetrazaomine, Lemonomycin, etc. Most of these natural compounds have strong antitumor activities, and its family member Ecteinasicdins743 (ET-743, Trabectedin) has been marketed in the European Union and the United States for the treatment of advanced soft tissue tumors and ovarian cancer. Because of the excellent biological activity and complex chemical structure of this kind of THIQ products, it has aroused great interest of biologists and chemists, and many synthetic chemists have paid considerable efforts to their total synthesis over the past decade. Based on this, the recent advances in the total synthesis of such THIQ alkaloids are reviewed.

引用

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