Recent advances of m6A methylation in skeletal system disease

被引：7

作者：

Liang, Jianhui ^{[1
,2
]}

Yi, Qian ^{[3
]}

Liu, Yang ^{[1
]}

Li, Jiachen ^{[1
,2
]}

Yang, Zecheng ^{[1
]}

Sun, Wei ^{[1
]}

Sun, Weichao ^{[1
,4
]}

机构：

[1] Shenzhen Univ, Shenzhen Peoples Hosp 2, Affiliated Hosp 1, Dept Orthoped,Hlth Sci Ctr, Shenzhen 518035, Guangdong, Peoples R China

[2] Shantou Univ, Med Coll, Shantou 515000, Peoples R China

[3] Southwest Med Univ, Sch Basic Med Sci, Dept Physiol, Luzhou 646099, Sichuan, Peoples R China

[4] Shenzhen Univ, Shenzhen Peoples Hosp 2, Affiliated Hosp 1, Cent Lab,Hlth Sci Ctr, Shenzhen 518035, Guangdong, Peoples R China

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2024年 / 22卷 / 01期

关键词：

m6A modification; Osteosarcoma; Osteoporosis; Rheumatoid arthritis; Osteoarthritis; MESSENGER-RNA; PROMOTES PROLIFERATION; READER YTHDF2; SELF-RENEWAL; NUCLEAR-RNA; OSTEOSARCOMA; CELLS; PROGRESSION; N6-METHYLADENOSINE; OSTEOARTHRITIS;

D O I：

10.1186/s12967-024-04944-y

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Skeletal system disease (SSD) is defined as a class of chronic disorders of skeletal system with poor prognosis and causes heavy economic burden. m6A, methylation at the N6 position of adenosine in RNA, is a reversible and dynamic modification in posttranscriptional mRNA. Evidences suggest that m6A modifications play a crucial role in regulating biological processes of all kinds of diseases, such as malignancy. Recently studies have revealed that as the most abundant epigentic modification, m6A is involved in the progression of SSD. However, the function of m6A modification in SSD is not fully illustrated. Therefore, make clear the relationship between m6A modification and SSD pathogenesis might provide novel sights for prevention and targeted treatment of SSD. This article will summarize the recent advances of m6A regulation in the biological processes of SSD, including osteoporosis, osteosarcoma, rheumatoid arthritis and osteoarthritis, and discuss the potential clinical value, research challenge and future prospect of m6A modification in SSD.

引用

页数：19