Clinical Pathway for Coronary Atherosclerosis in Patients Without Conventional Modifiable Risk Factors JACC State-of-the-Art Review

被引：40

作者：

Figtree, Gemma A. ^{[1
,2
,3
]}

Vernon, Stephen T. ^{[1
,2
,3
]}

Harmer, Jason A. ^{[3
]}

Gray, Michael P. ^{[1
,2
]}

Arnott, Clare ^{[4
,5
]}

Bachour, Eric ^{[6
]}

Barsha, Giannie ^{[1
,2
]}

Brieger, David

Brown, Alex ^{[8
,9
]}

Celermajer, David S. ^{[1
,5
,7
]}

Channon, Keith M. ^{[10
]}

Chew, Nicholas W. S. ^{[11
]}

Chong, James J. H. ^{[12
,13
,14
]}

Chow, Clara K. ^{[12
,14
]}

Cistulli, Peter A. ^{[15
,16
]}

Ellinor, Patrick T. ^{[17
,18
]}

Grieve, Stuart M. ^{[19
,20
]}

Guzik, Tomasz J. ^{[21
,22
,23
]}

Hagstrom, Emil ^{[24
]}

Jenkins, Alicia ^{[25
,26
]}

Jennings, Garry

Keech, Anthony C. ^{[25
]}

Kott, Katharine A.

Kritharides, Leonard ^{[1
,27
]}

Mamas, Mamas A. ^{[28
,29
]}

Mehran, Roxana ^{[30
]}

Meikle, Peter J. ^{[31
]}

Natarajan, Pradeep ^{[32
,33
,34
,35
]}

Negishi, Kazuaki ^{[36
]}

O'Sullivan, John ^{[1
,37
,38
]}

Patel, Sanjay ^{[1
,38
]}

Psaltis, Peter J. ^{[39
,40
,41
]}

Redfern, Julie ^{[5
,42
]}

Steg, Philippe G. ^{[43
,44
]}

Sullivan, David R. ^{[45
]}

Sundstrom, Johan ^{[46
]}

Vogel, Birgit ^{[30
]}

Wilson, Andrew ^{[47
]}

Wong, Dennis ^{[48
,49
]}

Bhatt, Deepak L. ^{[50
]}

Kovacic, Jason C. ^{[30
,51
,52
]}

Nicholls, Stephen J. ^{[53
]}

机构：

[1] Univ Sydney, Sydney Med Sch, Fac Med & Hlth, Sydney, NSW, Australia

[2] Kolling Inst Med Res, Cardiovasc Discovery Grp, St Leonards, NSW, Australia

[3] Royal North Shore Hosp, Dept Cardiol, St Leonards, NSW, Australia

[4] UNSW, George Inst Global Hlth, Fac Med, Sydney, NSW, Australia

[5] Royal Prince Alfred Hosp, Dept Cardiol, Camperdown, NSW, Australia

[6] Agile Grp Switzerland AG, Consumer Representat, Zug, Switzerland

[7] Concord Repatriat Gen Hosp, Dept Cardiol, Concord, Australia

[8] Australian Natl Univ, Natl Ctr Indigenous Genom, Canberra, ACT, Australia

[9] Telethon Kids Inst, Nedlands, WA, Australia

[10] Univ Oxford, Radcliffe Dept Med, British Heart Fdn Ctr Res Excellence, Oxford, England

[11] Natl Univ Heart Ctr, Natl Univ Hlth Syst, Dept Cardiol, Singapore, Singapore

[12] Univ Sydney, Westmead Appl Res Ctr, Fac Med & Hlth, Westmead, NSW, Australia

[13] Univ Sydney, Westmead Inst Med Res, Westmead, NSW, Australia

[14] Westmead Hosp, Dept Cardiol, Westmead, NSW, Australia

[15] Univ Sydney, Charles Perkins Ctr, Camperdown, NSW, Australia

[16] Royal North Shore Hosp, Dept Resp Sleep Med, St Leonards, NSW, Australia

[17] Broad Inst MIT & Harvard, Cardiovasc Dis Initiat, Cambridge, MA USA

[18] Massachusetts Gen Hosp, Demoulas Ctr Cardiac Arrhythmias, Boston, MA USA

[19] Royal Prince Alfred Hosp, Dept Radiol, Camperdown, NSW, Australia

[20] Univ Sydney, Charles Perkins Ctr, Imaging & Phenotyping Lab, Sydney, NSW, Australia

[21] Univ Edinburgh, Queens Med Res Inst, Ctr Cardiovasc Sci, Edinburgh, Midlothian, Scotland

[22] Jagiellonian Univ, Dept Internal Med, Med Coll, Krakow, Poland

[23] Jagiellonian Univ, Omicron Med Genom Lab, Med Coll, Krakow, Poland

[24] Uppsala Univ, Dept Med Sci, Cardiol, Uppsala, Sweden

[25] Univ Sydney, Nat Hlth & Med Res Council Clin Trials Ctr, Camperdown, NSW, Australia

[26] Baker Heart & Diabet Inst, Diabetes & Vasc Med, Melbourne, Vic, Australia

[27] Concord Repatriat Gen Hosp, ANZAC Res Inst, Concord, Australia

[28] Keele Univ, Keele Cardiovasc Res Grp, Ctr Prognost Res, Keele, Staffs, England

[29] Royal Stoke Univ Hosp, Dept Cardiol, Stoke On Trent, Staffs, England

[30] Icahn Sch Med Mt Sinai, Zena & Michael Wiener Cardiovasc Inst, New York, NY USA

[31] Baker Heart & Diabet Inst, Melbourne, Australia

[32] Massachusetts Gen Hosp, Cardiovas Res Ctr, Boston, MA USA

[33] Harvard Med Sch, Dept Med, Boston, MA USA

[34] Broad Inst MIT & Harvard, Program Med & Populat Genet & Cardiovasc Dis Inti, Cambridge, MA USA

[35] MIT, Cambridge, MA USA

[36] Nepean Hosp, Dept Cardiol, Kingswood, NSW, Australia

[37] Univ Sydney, Precis Cardiovasc Lab, Camperdown, NSW, Australia

[38] Univ Sydney, Heart Res Inst, Camperdown, NSW, Australia

[39] SAHMRI, Heart & Vasc Program, Vasc Res Ctr, Lifelong Hlth Theme, Adelaide, SA, Australia

[40] Univ Adelaide, Adelaide Med Sch, Adelaide, SA, Australia

[41] Royal Adelaide Hosp, Cent Adelaide Local Hlth Network, Dept Cardiol, Adelaide, SA, Australia

[42] Univ Sydney, Sydney Sch Hlth Sci, Fac Med & Hlth, Camperdown, NSW, Australia

[43] Univ Paris, Assistance Publ Hop Paris, French Alliance Cardiovasc Trials, Paris, France

[44] INSERM, Unite 1148, Paris, France

[45] Royal Prince Alfred Hosp, Dept Chem Pathol, Camperdown, NSW, Australia

[46] Uppsala Univ, Dept Med Sci, Uppsala, Sweden

[47] Univ Sydney, Sydney Sch Publ Hlth, Fac Med & Hlth, Menzies Ctr Hlth Policy & Econ, Camperdown, NSW, Australia

[48] Monash Univ, Monash Cardiovasc Res Ctr, Clayton, Vic, Australia

[49] Monash Hlth, MonashHeart, Clayton, Vic, Australia

[50] Icahn Sch Med Mt Sinai, Mt Sinai Hlth Syst, New York, NY USA

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2023年 / 82卷 / 13期

基金：

英国医学研究理事会; 欧盟地平线“2020”;

关键词：

CARDIOVASCULAR-DISEASE RISK; OBSTRUCTIVE SLEEP-APNEA; ACUTE MYOCARDIAL-INFARCTION; HEART-DISEASE; CLONAL HEMATOPOIESIS; PHYSICAL-ACTIVITY; SECONDARY PREVENTION; SCIENTIFIC STATEMENT; PERIODONTAL-DISEASE; VASCULAR-DISEASE;

D O I：

10.1016/j.jacc.2023.06.045

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Reducing the incidence and prevalence of standard modifiable cardiovascular risk factors (SMuRFs) is critical to tackling the global burden of coronary artery disease (CAD). However, a substantial number of individuals develop coronary atherosclerosis despite no SMuRFs. SMuRFless patients presenting with myocardial infarction have been observed to have an unexpected higher early mortality compared to their counterparts with at least 1 SMuRF. Evidence for optimal management of these patients is lacking. We assembled an international, multidisciplinary team to develop an evidence-based clinical pathway for SMuRFless CAD patients. A modified Delphi method was applied. The resulting pathway confirms underlying atherosclerosis and true SMuRFless status, ensures evidence-based secondary prevention, and considers additional tests and interventions for less typical contributors. This dedicated pathway for a previously overlooked CAD population, with an accompanying registry, aims to improve outcomes through enhanced adherence to evidence-based secondary prevention and additional diagnosis of modifiable risk factors observed. (c) 2023 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：1343 / 1359

页数：17

共 118 条

[1] Validity of the patient health questionnaire (PHQ-9) as a screening tool for depression amongst Nigerian university students [J].

Adewuya, Abiodun O. ;

ola, B. A. Ola ;

O Afolabi, Olusegun .

JOURNAL OF AFFECTIVE DISORDERS, 2006, 96 (1-2) :89-93

[2] Heavy Metals and Cardiovascular Disease: Results from the National Health and Nutrition Examination Survey (NHANES) 1999-2006 [J].

Agarwal, Shikhar ;

Zaman, Tarique ;

Tuzcu, E. Murat ;

Kapadia, Samir R. .

ANGIOLOGY, 2011, 62 (05) :422-429

[3] Impact of traditional and novel risk factors on the relationship between socioeconomic status and incident cardiovascular events [J].

Albert, Michelle A. ;

Glynn, Robert J. ;

Buring, Julie ;

Ridker, Paul M. .

CIRCULATION, 2006, 114 (24) :2619-2626

[4] Polygenic Scores to Assess Atherosclerotic Cardiovascular Disease Risk Clinical Perspectives and Basic Implications [J].

Aragam, Krishna G. ;

Natarajan, Pradeep .

CIRCULATION RESEARCH, 2020, 126 (09) :1159-1177

[5] Do Wearable Activity Trackers Increase Physical Activity Among Cardiac Rehabilitation Participants? A SYSTEMATIC REVIEW AND META-ANALYSIS [J].

Ashur, Carmel ;

Cascino, Thomas M. ;

Lewis, Christopher ;

Townsend, Whitney ;

Sen, Ananda ;

Pekmezi, Dorothy ;

Richardson, Caroline R. ;

Jackson, Elizabeth A. .

JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION, 2021, 41 (04) :249-256

[6] Coronary artery disease in the absence of traditional risk factors: a call for action [J].

Avis, Suzanne R. ;

Vernon, Stephen T. ;

Hagstrom, Emil ;

Figtree, Gemma A. .

EUROPEAN HEART JOURNAL, 2021, 42 (37) :3822-3824

[7] Cardiovascular Health of Patients With Cancer and Cancer Survivors A Roadmap to the Next Level [J].

Barac, Ana ;

Murtagh, Gillian ;

Carver, Joseph R. ;

Chen, Ming Hui ;

Freeman, Andrew M. ;

Herrmann, Joerg ;

Iliescu, Cezar ;

Ky, Bonnie ;

Mayer, Erica L. ;

Okwuosa, Tochi M. ;

Plana, Juan Carlos ;

Ryan, Thomas D. ;

Rzeszut, Anne K. ;

Douglas, Pamela S. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2015, 65 (25) :2739-2746

[8] The Link Between Obstructive Sleep Apnea and Cardiovascular Disease [J].

Bauters, Fre ;

Rietzschel, Ernst R. ;

Hertegonne, Katrien B. C. ;

Chirinos, Julio A. .

CURRENT ATHEROSCLEROSIS REPORTS, 2016, 18 (01) :1-11

[9] Association of Diet Quality With Prevalence of Clonal Hematopoiesis and Adverse Cardiovascular Events [J].

Bhattacharya, Romit ;

Zekavat, Seyedeh Maryam ;

Uddin, Md Mesbah ;

Pirruccello, James ;

Niroula, Abhishek ;

Gibson, Christopher ;

Griffin, Gabriel K. ;

Libby, Peter ;

Ebert, Benjamin L. ;

Bick, Alexander ;

Natarajan, Pradeep .

JAMA CARDIOLOGY, 2021, 6 (09) :1069-1077

[10] Inherited causes of clonal haematopoiesis in 97,691 whole genomes [J].

Bick, Alexander G. ;

Weinstock, Joshua S. ;

Nandakumar, Satish K. ;

Fulco, Charles P. ;

Bao, Erik L. ;

Zekavat, Seyedeh M. ;

Szeto, Mindy D. ;

Liao, Xiaotian ;

Leventhal, Matthew J. ;

Nasser, Joseph ;

Chang, Kyle ;

Laurie, Cecelia ;

Burugula, Bala Bharathi ;

Gibson, Christopher J. ;

Lin, Amy E. ;

Taub, Margaret A. ;

Aguet, Francois ;

Ardlie, Kristin ;

Mitchell, Braxton D. ;

Barnes, Kathleen C. ;

Moscati, Arden ;

Fornage, Myriam ;

Redline, Susan ;

Psaty, Bruce M. ;

Silverman, Edwin K. ;

Weiss, Scott T. ;

Palmer, Nicholette D. ;

Vasan, Ramachandran S. ;

Burchard, Esteban G. ;

Kardia, Sharon L. R. ;

He, Jiang ;

Kaplan, Robert C. ;

Smith, Nicholas L. ;

Arnett, Donna K. ;

Schwartz, David A. ;

Correa, Adolfo ;

de Andrade, Mariza ;

Guo, Xiuqing ;

Konkle, Barbara A. ;

Custer, Brian ;

Peralta, Juan M. ;

Gui, Hongsheng ;

Meyers, Deborah A. ;

McGarvey, Stephen T. ;

Chen, Ida Yii-Der ;

Shoemaker, M. Benjamin ;

Peyser, Patricia A. ;

Broome, Jai G. ;

Gogarten, Stephanie M. ;

Wang, Fei Fei .

NATURE, 2020, 586 (7831) :763-+

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